DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GRID1

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	479	Identity:	86/479 - (17%)
Similarity:	175/479 - (36%)	Gaps:	104/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 GLTKPLFPRKL-TNMHGCEMVVATFEHRPYVIIEDD----PKTPGGRSIHGIEGLIFRSLAERMN 257
            ||...|..|.: :.:.|..:.|.|....|:|::.::    ||...|.||.     :..:||:.:.
Human   420 GLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSID-----VLDALAKALG 479

  Fly   258 FTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLV 322
            |..::.:..|...|..|.:.::.|::..::....:|.......:..|..::..|..|..:.:.::
Human   480 FKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGIL 544

  Fly   323 VPSGGSISPMGRLTRPFRYIIWSCILVSL-IFGFVLICLLKITALPGLRNLVLGRRNRLPFMGMW 386
            :........:..|..||.:.:|:||..:: :.|.::..|.:|.|       |..:....|.....
Human   545 IKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQA-------VRAQSAAQPRPSAS 602

  Fly   387 ASL-------------LGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPI 438
            |:|             .||.:..|...  .|.::..|.|.|||:.::||..|...|....|.:||
Human   603 ATLHSAIWIVYGAFVQQGGESSVNSMA--MRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPI 665

  Fly   439 KSLSEV---------------------------LAKDYEFRILPALRTIFKD-------SMPTT- 468
            ::..::                           |.:|..|..|  .|||.|:       |.|:.
Human   666 RTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAEL--WRTISKNGGADNCVSSPSEG 728

  Fly   469 -------NFHAVLSLEESLYRLRDEDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPL 526
                   |:..:..:....|....:||..:                       ||:.:.:.:...
Human   729 IRKAKKGNYAFLWDVAVVEYAALTDDDCSV-----------------------TVIGNSISSKGY 770

  Fly   527 TFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVS----KRRNLEPKPLSIWRLSGIF 587
            ...::..|.::....:.|:.:..:|.:...::.:...:.|..    .....:.|.|.:...:|:|
Human   771 GIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVF 835

  Fly   588 VCCAGLYLVALIVFILEILTTNHR 611
            ...|...|:|.:|..||:...::|
Human   836 CILAIGLLLACLVAALELWWNSNR 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	14/65 (22%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	52/309 (17%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		4/15 (27%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	2/2 (100%)
		ANF_receptor	41..400	CDD:279440
		PBP2_iGluR_delta_1	436..806	CDD:270448	70/408 (17%)
		Lig_chan	564..841	CDD:278489	52/310 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740