DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and GRIA1

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	462	Identity:	92/462 - (19%)
Similarity:	177/462 - (38%)	Gaps:	96/462 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 VVATFEHRPYVIIEDDPKTPGGRSIHGIEGL---IFRSLAERMNFTIKLVEQKDKNRGEILPDGN 278
            :|.|....|||:::.:.....|...:  ||.   :...:|:.:.::.:|         ||:.||.
Human   420 IVTTILEDPYVMLKKNANQFEGNDRY--EGYCVELAAEIAKHVGYSYRL---------EIVSDGK 473

  Fly   279 F----------TGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP-M 332
            :          .|::..:|.|..::.......:..|.:::..|..:.|..|.:::.......| :
Human   474 YGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 538

  Fly   333 GRLTRPFRYIIWSCILVSLIFGFVLICLLKITALP----------GLRNLVLGRRNRLP-FMGMW 386
            .....|..|.||.||:.:.| |..::..|.....|          |.......:.|... |..:|
Human   539 FSFLDPLAYEIWMCIVFAYI-GVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLW 602

  Fly   387 ASLLGGLAL-----YNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLA 446
            .||  |..:     .:|:....|.:..:|...|||:.::||..|...|....|.|||:| :|.||
Human   603 FSL--GAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLA 664

  Fly   447 KDYE--------------FR-----ILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGIT 492
            |..|              ||     :...:.|..|.:.|:.   .|.:.||.:.|:|  ...|..
Human   665 KQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSV---FVRTTEEGMIRVR--KSKGKY 724

  Fly   493 VALLQPTVNQFDFRSGP-----------NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMA 546
            ..||:.|:|::..:..|           :|.:....|             ..|..:..::..::.
Human   725 AYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATP-------------KGSALRNPVNLAVLK 776

  Fly   547 MMSSGIVARYR-KMYMDRIKRVSKRRNLEPK--PLSIWRLSGIFVCCAGLYLVALIVFILEILTT 608
            :...|::.:.: |.:.|:.:..|...:.:.|  .||:..::|:|....|...:|::|.::|....
Human   777 LNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYK 841

  Fly   609 NHRRLRR 615
            :....:|
Human   842 SRSESKR 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	13/74 (18%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	63/298 (21%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385
		ANF_receptor	47..382	CDD:279440
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	81/409 (20%)
		Lig_chan	548..827	CDD:278489	64/300 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740