DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and Grik5

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	97/445 - (21%)
Similarity:	179/445 - (40%)	Gaps:	77/445 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 MVVATFEHRPYVIIEDDPKTPGGRSIHG---IEGL---IFRSLAERMNFTIKLVEQKDKNRGEIL 274
            :||.|....|||:     :.|..:::.|   .||.   :.|.|||.:.|..:|...:|...|...
  Rat   417 LVVTTILENPYVM-----RRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPE 476

  Fly   275 PDGNFTGILKMMVDGE-VNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISPMGR---- 334
            |:|::||::..:::.: .:|....|..:..|..::..|..:.:..|.::..     ..|||
  Rat   477 PNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYR-----VHMGRKPGY 536

  Fly   335 --LTRPFRYIIWSCILVSLIFGFVLICLLKITAL----------PGLR--------NLVLGRRNR 379
              ...||...:|..:|::.:   .:.|:|.:.|.          |.||        ...||....
  Rat   537 FSFLDPFSPAVWLFMLLAYL---AVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLW 598

  Fly   380 LP---FMGMWASLLGGLALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSL 441
            .|   ||...:.::       |:....|.:..:|...|||:.::||..|...|....|..|::|.
  Rat   599 FPVGGFMQQGSEIM-------PRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESA 656

  Fly   442 SEVLAK-DYEFRILPA--LRTIFKDSMPTT-----NFHA-------VLSLEESLYRLRDEDDPGI 491
            .::..: :.|:..:.|  ..|.|::|...|     |:..       |.|.||.:.|:.:..
  Rat   657 DDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR---- 717

  Fly   492 TVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARY 556
            ...||:.|:|::..|...|   ||.:...|.|......|...|.|:..|...|:.:..:..:...
  Rat   718 YAFLLESTMNEYHRRLNCN---LTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEIL 779

  Fly   557 RKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHR 611
            ::.:.:. .|..|..:...|.|.:..:.||||......::|:.|.::|.:.:..|
  Rat   780 KRKWWEG-GRCPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRR 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	19/67 (28%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	61/285 (21%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	85/394 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740