DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7c and gria2a

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	506	Identity:	97/506 - (19%)
Similarity:	191/506 - (37%)	Gaps:	108/506 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 QSSLPV---YYTAFQDLAAPANGFGLTK-PLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPG 237
            ::|.||   |:.....:|       :|| .|||.....|....::|.|....|||:::.:.:
Zfish   373 KNSGPVKIGYWNEMDKMA-------VTKSDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAE--- 427

  Fly   238 GRSIHGIEGLIFRSLAERMNFTIKLVEQKDKNRG-----EILPDGNF----------TGILKMMV 287
                      :|........:.:.|..:..|:.|     .|:.||.:          .|::..:|
Zfish   428 ----------LFTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELV 482

  Fly   288 DGEVNLTFVCFMYSKARSDLMLPSTSYTSFPIVLVVPSGGSISP-MGRLTRPFRYIIWSCILVSL 351
            .|:.::.......:..|.:::..|..:.|..|.:::.......| :.....|..|.||.||:.:.
Zfish   483 YGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAY 547

  Fly   352 IFGFVLICLLKITALP------GLRNLVLGRRNRLPFMGMWASLLGGLALY-------NPQRNFA 403
            | |..::..|.....|      ...:..||........|::.||...|..:       :|:....
Zfish   548 I-GVSVVLFLVSRFSPYEWHTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSG 611

  Fly   404 RYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLAKDYEFRILPALRTIFKDSMPTT 468
            |.:..:|...|||:.::||..|...|....|.|||:| :|.|||..|.    |..|:  |:..|.
Zfish   612 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLAKQTEI----AYGTL--DAGSTK 669

  Fly   469 NF--HAVLSLEESLYRLRDEDDPGITVA------------------LLQPTVNQFDFRSGP---- 509
            .|  .:.::|.:.:::.....:|.:.|.                  ||:.|:|::..:..|
Zfish   670 EFFRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTM 734

  Fly   510 -------NKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYR-KMYMDRIKR 566
                   :|.:....|             ..|..:..::..::.:...|::.:.: |.:.|:.:.
Zfish   735 KVGGNLDSKGYGIATP-------------KGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 786

  Fly   567 VSKRRNLEPK--PLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRR 615
            .|.....:.|  .||:..::|:|....|...:|::|.::|....:....:|
Zfish   787 GSGGGESKEKTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKR 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	11/76 (14%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	59/296 (20%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	5/24 (21%)
		ANF_receptor	51..373	CDD:279440	97/506 (19%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	74/410 (18%)
		Lig_chan	538..816	CDD:278489	60/298 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740