DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Grin2d

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	683	Identity:	136/683 - (19%)
Similarity:	235/683 - (34%)	Gaps:	191/683 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SGLTGRPIAIWFLDSLR------SYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFR 143
            :|||| |..:||:...:      |....|..|...|:|... |.|.|...|..|.       :.|
Mouse   265 AGLTG-PGYVWFMVGPQLAGGGGSGVPGEPLLLPGGAPLPA-GLFAVRSAGWRDD-------LAR 320

  Fly   144 RLLNMYVLNVNVF------LQRDGTVHLYTYYPYGPHHCQS--------SLPVYYTAF----QDL 190
            |:    ...|.|.      |.||     |.:.|...|.|::        ||..|:...    :|.
Mouse   321 RV----AAGVAVVARGAQALLRD-----YGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDY 376

  Fly   191 AAPANGFGLTKPLFPRKLTNMHGCEMV--------------------------------VATFEH 223
            :...:||.:...|....||.....|:|                                |||.|.
Mouse   377 SFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEE 441

  Fly   224 RPYVIIE----------------------------------DDPKTPGGRSIHGIEGLIFRSLAE 254
            ||:||:|                                  |.|: |..|...|....|.:.||.
Mouse   442 RPFVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPPDAPR-PEKRCCKGFCIDILKRLAH 505

  Fly   255 RMNFTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI 319
            .:.|:..|....:...|:.: ||.:.|::..:.....::.......::.||:::..|..:....|
Mouse   506 TIGFSYDLYLVTNGKHGKKI-DGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGI 569

  Fly   320 -VLVVPSGGSISPMGRLT----------RPFRYIIW-----SCILVSLIFGFVLICL-------- 360
             |:|..|.|::||...|.          .|:...:|     .|:.|..:..|:...|
Mouse   570 SVMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRS 634

  Fly   361 LKITALPGLRNLVLGRRNRLPFMGMWASLL-GGLALYNPQRNFARYILVMWLLQTLILRAAYTGQ 424
            |.....||.....:|:...|    :||.:. ..:.:.||:...::.::::|....:|..|:||..
Mouse   635 LATGKRPGGSTFTIGKSIWL----LWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTAN 695

  Fly   425 LYLLLQDVEMRSPIKSLSEVLAKDYEFRILPALRTIFKDSMPTTNFHAVL--SLEESL------- 480
            |...:...|....:..||     |.:|: .|      ::..|...|..|.  |.|:::
Mouse   696 LAAFMIQEEYVDTVSGLS-----DRKFQ-RP------QEQYPPLKFGTVPNGSTEKNIRSNYPDM 748

  Fly   481 --YRLRDEDDPGITVALLQPTVNQFD------------FRSGPNKRHLTVLPDPLM-TAPLTFYM 530
              |.:| .:.|.:..||.|....:.|            .|.....:.:|:....:. |......:
Mouse   749 HSYMVR-YNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIAL 812

  Fly   531 RPHSYFKRRIDRLIMAMMSSGIVARYRKMYM------DRIKRVSKRRNLEPKPLSIWRLSGIFVC 589
            ...|.:||.||..::..:....:....::::      |:|:.:|.:       |.|..::|:|..
Mouse   813 HKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSK-------LDIDNMAGVFYM 870

  Fly   590 CAGLYLVALIVFILEILTTNHRRLRRAFNVINR 622
            ......::|:||..|.|.  :.|||......:|
Mouse   871 LLVAMGLSLLVFAWEHLV--YWRLRHCLGPTHR 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/95 (19%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	53/293 (18%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	39/167 (23%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	81/435 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740