Protein Alignment Ir7c and Grin2b

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 645
• Identity: 123/645 - (19%)
• Similarity: 224/645 - (34%)
• Gaps: 182/645 - (28%)

  Fly    76 ETDTDPPP-PSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLED------- 132
            :|||.|.. |:||.......|                ..|.|.:......:|.|...|
Mouse   265 DTDTVPSEFPTGLISVSYDEW----------------DYGLPARVRDGIAIITTAASDMLSEHSF 313

  Fly   133 --QPMESL------KIMFRRLLNMYVLNV-----NVFLQRDGTVHLYTYYP-------------- 170
              :|..|.      :|....:||.|::||     |:....||    |..:|
Mouse   314 IPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDG----YQMHPKLVIILLNKERKWE 374

  Fly   171 -YGPHHCQSSLPVYYTAFQDLAAPANGFGLTKPLFPRKLTNMHGCE---MVVATFEHRPYVIIED 231
             .|....:|....||                  ::||........|   :.:.|.|..|:||:|.
Mouse   375 RVGKWKDKSLQMKYY------------------VWPRMCPETEEQEDDHLSIVTLEEAPFVIVES 421

  Fly   232 -DP--------------------KT---PG--GRSIHGIEGLIFRSLAERMNFTIKLVEQKDKNR 270
             ||                    ||   ||  .:...|....|.:.:::.:.||..|....:...
Mouse   422 VDPLSGTCMRNTVPCQKRIISENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKH 486

  Fly   271 GEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPMGR 334
            |:.: :|.:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||...
Mouse   487 GKKI-NGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAF 550

  Fly   335 LTRPFRYIIWSCILVSLIFGFVLICLLKITAL--------------------PGLRNLVLGRRNR 379
            | .||...:|       :..||::.::...|:                    ||..:..:|:
Mouse   551 L-EPFSADVW-------VMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGK--- 604

  Fly   380 LPFMGMWASLLGGLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPI 438
                .:|  ||.||.      :.||:...::.::.:|....:|..|:||..|...:...|....:
Mouse   605 ----AIW--LLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663

  Fly   439 KSLSEV-------LAKDYEFRILPALRTIFKDSMPTTNFHAVLSLEESLYRLRDEDDPGITVALL 496
            ..||:.       .:..:.|..:|...|    .....|.:|.:......:..|..||     |||
Mouse   664 SGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMGKFNQRGVDD-----ALL 719

  Fly   497 QPTVNQFD----------FRSGPNK--RHLTVLPDPLMTAPLTFY---MRPHSYFKRRIDRLIMA 546
            .....:.|          :.:|.::  :.:|:....:..:  |.|   ::..|.:||::|..|:.
Mouse   720 SLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAS--TGYGIAIQKDSGWKRQVDLAILQ 782

  Fly   547 MMSSGIVARYRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL 606
            :...|.:.....:::..|.. :::..:....|.|..::|:|........::||.||.|.|
Mouse   783 LFGDGEMEELEALWLTGICH-NEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHL 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/87 (21%)
		Lig_chan	343..592	CDD:459656	50/296 (17%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	28/142 (20%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	80/429 (19%)
		NMDAR2_C	840..1482	CDD:463148	1/2 (50%)