DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Grin2a

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_032196.2	Gene:	Grin2a / 14811	MGIID:	95820	Length:	1464	Species:	Mus musculus

Alignment Length:	704	Identity:	140/704 - (19%)
Similarity:	265/704 - (37%)	Gaps:	155/704 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 WAIDNYYGMATSTPLAVVQFPTSRESRRLHNDLIDAALGRSSGTGRIQFLLEDDRV-EMTETDTD 80
            |.:.|...:.||...|..|.    :.:::|:.:|            :.:..:|:.| .::|..:
Mouse   198 WDMQNVITLDTSFEDAKTQV----QLKKIHSSVI------------LLYCSKDEAVLILSEARS- 245

  Fly    81 PPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVIYTGLEDQPMESLKIMFRRL 145
                .||||... .|.:.||.| ...|:...:..|     |...|.|    |....||:...|..
Mouse   246 ----LGLTGYDF-FWIVPSLVS-GNTELIPKEFPS-----GLISVSY----DDWDYSLEARVRDG 295

  Fly   146 LNMYVLNVNVFLQRDGTVHLYTYYP------YG-------PHHCQSSLPVYYT-AFQDLAAPANG 196
            |.:.....:..|::      ::|.|      ||       |.|......|..| ..:||:....|
Mouse   296 LGILTTAASSMLEK------FSYIPEAKASCYGQTEKPETPLHTLHQFMVNVTWDGKDLSFTEEG 354

  Fly   197 F----------------------------GLTKPLFPRKLTNMHGCE-----MVVATFEHRPYVI 228
            :                            .|...::|| ..:...||     :.:.|.|..|:||
Mouse   355 YQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPR-YKSFSDCEPDDNHLSIVTLEEAPFVI 418

  Fly   229 IED-DPKT--------PGGRSI----HGIEGL------------IFRSLAERMNFTIKLVEQKDK 268
            :|| ||.|        |..:.:    ...||:            |.:.|:..:.||..|....:.
Mouse   419 VEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNG 483

  Fly   269 NRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLPSTSYTSFPI-VLVVPSGGSISPM 332
            ..|:.: :..:.|::..:|.....:.......::.||:::..|..:....| |:|..|.|::||.
Mouse   484 KHGKKV-NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS 547

  Fly   333 GRLTRPFRYIIWSCILVS-LIFGFVLICLLKITALPGL-RNLVLGRRNRLPFM----GMWASLLG 391
            ..| .||...:|..:.|. ||...:.:.:.:..:..|. |||..|:....|..    .:|  ||.
Mouse   548 AFL-EPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIW--LLW 609

  Fly   392 GLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEV------ 444
            ||.      :.||:...::.::.:|....:|..|:||..|...:...|....:..||:.
Mouse   610 GLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPH 674

  Fly   445 -LAKDYEFRILP--ALRTIFKDSMP-----TTNFHAVLSLEESLYRLRDEDDPGITVALLQPTVN 501
             .:..:.|..:|  :.....:::.|     .|.|:. ..:|::|..|:    .|...|.:....
Mouse   675 DYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQ-RGVEDALVSLK----TGKLDAFIYDAA- 733

  Fly   502 QFDFRSGPNK--RHLTVLPDPLM-TAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDR 563
            ..::::|.::  :.:|:....:. |......::..|.:||:||..::..:..|.:.....:::..
Mouse   734 VLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798

  Fly   564 IKRVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEILTTNHRRLRRAF 617
            |.. :::..:....|.|..::|:|...|....::||.||.|.|.  :.:||..|
Mouse   799 ICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF--YWKLRFCF 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/86 (21%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	51/278 (18%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	42/231 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	80/409 (20%)
		HisJ	<458..>541	CDD:223904	14/83 (17%)
		Lig_chan	556..828	CDD:278489	51/280 (18%)
		NMDAR2_C	839..1464	CDD:287527	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840