DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and Grik2

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	718	Identity:	143/718 - (19%)
Similarity:	238/718 - (33%)	Gaps:	248/718 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHSAVHNVSLVYALVWAIDNYYGMATSTPLAVVQFP----TSRESRRLHNDLIDAALGRSSGTG 61
            :::.|||.||                    :||.|||    :|.:..| |...       ..||
Mouse   322 LMYDAVHVVS--------------------VAVQQFPQMTVSSLQCNR-HKPW-------RFGT- 357

  Fly    62 RIQFLLEDDRVEMTETDTDPPPPSGLTGRPIAIWFLDSLRSYFRLEMYLNQLGSPYKRNGFFLVI 126
            |...|:::...|            ||||| |.....:.||:.|.|::
Mouse   358 RFMSLIKEAHWE------------GLTGR-ITFNKTNGLRTDFDLDV------------------ 391

  Fly   127 YTGLEDQPMESLKIMFRRLLNMYVLNVNVFLQRDGTVHLYTYYPYGPHHCQSSLPVYYTAFQDLA 191
                                        :.|:.:|...:.|:.|        |..:..|..|. .
Mouse   392 ----------------------------ISLKEEGLEKIGTWDP--------SSGLNMTESQK-G 419

  Fly   192 APANGFGLTKPLFPRKLTNMHGCEMVVATFEHRPYVIIEDDPKTPGGRSIHGIEGL---IFRSLA 253
            .|||   :|..|..|.|        :|.|....|||:.:...|...|..  ..||.   :.|.|:
Mouse   420 KPAN---ITDSLSNRSL--------IVTTILEEPYVLFKKSDKPLYGND--RFEGYCIDLLRELS 471

  Fly   254 ERMNFT--IKLVE------QKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLP 310
            ..:.||  |:|||      |.|.|       |.:.|:::.::|.:.:|.......:..|..::..
Mouse   472 TILGFTYEIRLVEDGKYGAQDDVN-------GQWNGMVRELIDHKADLAVAPLAITYVREKVIDF 529

  Fly   311 STSYTSFPIVLVVPSGGSISP-MGRLTRPFRYIIWSCILVSLIFGFVLICLLKITALPGLRNLVL 374
            |..:.:..|.::.......:| :.....|....||..||::.:   .:.|:|          .|:
Mouse   530 SKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYL---GVSCVL----------FVI 581

  Fly   375 GRRNRLPFMG----------------------MWASLLGGLALYNP----------QRNF----- 402
            .|:::..:..                      |...|......|||          :.||
Mouse   582 ARQSKFSWFKYPNCSHYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNS 646

  Fly   403 ---------------------ARYILVMWLLQTLILRAAYTGQLYLLLQDVEMRSPIKSLSEVLA 446
                                 .|.:..:|...|||:.::||..|...|....|.|||.|..: ||
Mouse   647 FWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD-LA 710

  Fly   447 KD--YEFRILP--ALRTIFKDSMPTT----------NFHAVL--SLEESLYRLRDEDDPGITVAL 495
            |.  .|:..:.  |..|.||.|..:|          ...:||  |.||.:.|:...|    ...|
Mouse   711 KQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD----YAFL 771

  Fly   496 LQPTVNQFDFRSGPNKRHLTVLPDPL---MTAPLTFYMRPHSYFKRRIDRLIMAMMSSGIVARYR 557
            ::.|..:|..:...|...:..|.|..   :..|:      .|.::.:|...|:.:...|
Mouse   772 MESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPM------GSPYRDKITIAILQLQEEG------ 824

  Fly   558 KMYMDRIK-----RVSKRRNLEPKPLSIWRLSGIFVCCAGLYLVALIVFILEIL---TTNHRRLR 614
            |::|.:.|     ...:..:.|...|.:..:.|||:..|...::::.|.:.|.|   ..|.:..:
Mouse   825 KLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 889

  Fly   615 RAF 617
            |:|
Mouse   890 RSF 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	20/72 (28%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	66/331 (20%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	33/187 (18%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	91/451 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846624
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930