DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7c and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001245572.1	Gene:	Ir7c / 31692	FlyBaseID:	FBgn0029966	Length:	625	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	492	Identity:	99/492 - (20%)
Similarity:	180/492 - (36%)	Gaps:	114/492 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 VVATFEHRPYVI---IEDDPKTPGGR------------------SIHGIEGLI------------ 248
            ||...|| |:|.   ::|:...|.|:                  |:|.....:
Human   517 VVTLIEH-PFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYC 580

  Fly   249 ---FRSLAERMNFTIKLVEQKDKNRGEILPDGNFTGILKMMVDGEVNLTFVCFMYSKARSDLMLP 310
               ...:||.|||...|....|...| ...:|::||::..::.|..::....|..:.|||.::..
Human   581 IDLLEKIAEDMNFDFDLYIVGDGKYG-AWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDF 644

  Fly   311 STSYTSFPIVLVVPSGGSISPMGRLTRPFRYIIWSCILVSLIFGFVLICLLKITALPGLRNLVLG 375
            ::.:.|..:.::|.:..:.:|:|....|..:.:|..|.|:|....|.:.|.:..:..||......
Human   645 TSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRN 709

  Fly   376 RRNRLPF---MGMWASLLGG--LALYNPQRNFARYILVMWLLQTLILRAAYTGQLYLL------- 428
            |.....|   :.:..:||.|  :|:..|:....|:::.:|.:..:...:.||..|..:
Human   710 RSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIY 774

  Fly   429 -----LQDVEMRSPIK-----SLSEVLAKDYEFRILPALRTIFKD-SMPTTNFHAVLSLEESLYR 482
                 :.|.::..|.:     ::.|..|:||..:..|.:....:. ::|.|        .:.:..
Human   775 EELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPAT--------PDGVEY 831

  Fly   483 LRDEDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPLTFYMRPHSYFKRRIDRLIMAM 547
            |:: |...:...::...:..::.....:.:.||| ..|.........:.|:|.....|..||...
Human   832 LKN-DPEKLDAFIMDKALLDYEVSIDADCKLLTV-GKPFAIEGYGIGLPPNSPLTANISELISQY 894

  Fly   548 MSSGIVARYRKMYMDRIKRV---SKR--RNLEPKPLSIWRLSGIFV-CCAGLYLVALIVFILEIL 606
            .|.|    :..|..|:..||   .||  ...|...:.|...||:|| .|.|        |.|.||
Human   895 KSHG----FMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIG--------FGLSIL 947

  Fly   607 TT-------------------------NHRRLRRAFN 618
            ||                         ..:||.||.|
Human   948 TTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAIN 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_001245572.1	Lig_chan-Glu_bd	225..287	CDD:214911	18/97 (19%)
Ir7c	NP_001245572.1	Lig_chan	343..593	CDD:278489	55/278 (20%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	76/406 (19%)
		Lig_chan	676..942	CDD:278489	56/287 (20%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		5/34 (15%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740