Protein Alignment Ir7c and grin2ca

DIOPT Version :10

• Sequence 1: NP_572411.1
• Gene: Ir7c / 31692
• FlyBaseID: FBgn0029966
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 668
• Identity: 134/668 - (20%)
• Similarity: 233/668 - (34%)
• Gaps: 220/668 - (32%)

  Fly    86 GLTGRPIAIWFLDSLRSYFRLEMYLNQLGSP-------------------YK-------RNGFFL 124
            ||.| |..|||:.||           .:|:|                   :|       |:|..:
Zfish   254 GLVG-PGYIWFIPSL-----------AVGNPNIAPPDSFPVGLISIITDRWKMSLRNRVRDGVAI 306

  Fly   125 VIYTGLE----------DQPMESLK--------IMFRRLLNMYVLNVNVFLQRDGTVHLYTYYPY 171
            |: .|:|          |..|:.|.        .::|.:||:...|.:.....||       |..
Zfish   307 VV-KGVESFRKQRGFIPDGHMDCLSPIRPASNGTLYRHMLNVSWENTDFSFNSDG-------YLV 363

  Fly   172 GPHHCQSSLPVYYTAFQDLAAPANGFG--------LTKPLFPRKLT-------NMHGCEMVVATF 221
            .|.....:|        |.....:..|        :..|::||..|       |.|   :.|||.
Zfish   364 NPSMIIITL--------DRGRQWDKVGNYESGILQMRYPVWPRYGTFLEPVSDNRH---LTVATL 417

  Fly   222 EHRPYVIIED-DPKT--------PGGRSIHGIEGL------------------IFRSLAERMNFT 259
            |.||:||:|. ||.|        |..|..:..|.:                  |.:.|:..:.|:
Zfish   418 EERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFS 482

  Fly   260 IKLVEQKDKNRGEILPDGNFTGILKMMVDGEV-----NLTFVCFMYSKARSDLMLPSTSYTSFPI 319
            ..|....:...|:::     .||...|: |||     ::.......::.||:::..|..:....|
Zfish   483 YDLYLVTNGKHGKLV-----RGIWNGMI-GEVFYKRADMAIGSLTINEERSEIIDFSVPFVETGI 541

  Fly   320 -VLVVPSGGSISPMGRLTRPFRYIIW-----SCILVSLIFGFVL-IC-------LLKITALPGLR 370
             |:|..|.|::||...| .|:...:|     .|:.|..:..||. .|       .|.....||..
Zfish   542 SVMVARSNGTVSPSAFL-EPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYNRSLVSAKDPGGP 605

  Fly   371 NLVLGRRNRLPFMGMWASLLGGLA------LYNPQRNFARYILVMWLLQTLILRAAYTGQLYLLL 429
            ...:|:       .:|  ||.|:.      :.||:...::.::::|....:|..|:||..|...:
Zfish   606 TFTIGK-------SVW--LLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFM 661

  Fly   430 QDVEMRSPIKSLSEVLAK-------DYEFRILP--ALRTIFKDSMPTTNFHAV----LSLEESLY 481
            ...:....:..||:...:       .:.|..:|  :.....:.:.|..:.|.|    ..:|::|.
Zfish   662 IQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYPEMHSHMVKYNQKGVEDALN 726

  Fly   482 RL--------------------RDEDDPGITVALLQPTVNQFDFRSGPNKRHLTVLPDPLMTAPL 526
            .|                    :||....:|:              |..|...|
Zfish   727 SLKTGKLDAFIYDAAVLNYMAGKDEGCKLVTI--------------GSGKVFAT----------- 766

  Fly   527 TFY---MRPHSYFKRRIDRLIMAMMSSGIVARYRKMYMDRIKRVSKRRNLEPKPLSIWRLSGIFV 588
            |.|   ::..|.:||.||..::..::.|...:.:.:::..|.|..|:..:..| |.|..::|:|.
Zfish   767 TGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLTGICRNEKKEVMSSK-LDIDNMAGVFY 830

  Fly   589 CCAGLYLVALIVFILEIL 606
            .......::|:||..|.|
Zfish   831 MLLVAMGLSLLVFAWEHL 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7c	NP_572411.1	Lig_chan-Glu_bd	225..287	CDD:214911	17/88 (19%)
		Lig_chan	343..592	CDD:459656	54/303 (18%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	31/166 (19%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	87/444 (20%)
		NMDAR2_C	847..>938	CDD:463148	1/2 (50%)