DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and gria1a

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	772	Identity:	133/772 - (17%)
Similarity:	252/772 - (32%)	Gaps:	249/772 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LAEALAQVVANSEMGRFKTLYIYTHTN---------------SQSTGGHLEELLDQVLMIVPNNL 75
            |...|.:::   |:|:....|.|...|               :..||..|....|      ||..
Zfish   208 LTSILKKII---ELGKNVKSYHYILANLGFLDIDLTEFKKGEANVTGFQLVNYAD------PNVS 263

  Fly    76 QARRLLLQQSMEYK-----------PYVHAVLALVDGLPSLSAIYARIRATQ-DLS---HTLIYM 125
            :.    :||.||:.           .|..|:  ..||:..:|..:..:|..: |:|   :....:
Zfish   264 RT----VQQWMEFDNKDAKVPKRRLKYTGAL--TYDGVKVMSTAFQNLRRQRIDISRRGNAGECL 322

  Fly   126 SMPTDAYGE--EMQATL-------------------RFLWRLSVLNVGVVLRPPG---------- 159
            :.|...:|:  ::|..|                   |..:.:||:.    |||.|
Zfish   323 ANPPAPWGQGIDIQRALQQVRIEGLTGHIQFNEKGRRTNYSISVME----LRPTGPKKVGYWNED 383

  Fly   160 -DHILMVSYFPFS-ALHGCQVISANVVNRYQVGTKRWASQDYFPSKLGNFYGCLLTCATWEDMPY 222
             ..:...:|.|.| ..:|.|       ||..:.|                        |..:.||
Zfish   384 EKFVSTAAYMPGSNETYGLQ-------NRTYIVT------------------------TILESPY 417

  Fly   223 LVWRPDGSGSFVG---IEGALLQFMAENLNFTVGLYWMNKEEVLA----------TFDESGRIFD 274
            ::.:.:.. .|.|   .||..::..|| :...||.:::.|  ::|          |...:|.:.:
Zfish   418 VMLKKNHE-HFTGNDKYEGYCVELAAE-IAKHVGYHYILK--IVADGKYGARDAETMMWNGMVGE 478

  Fly   275 EIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFPFTPLLW 336
            .::| .||.::............|.:|:.   |||   .||:....:|....:..|. |....:|
Zfish   479 LVYG-KADVAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPTKSKPGVFSFLD-PLAYEIW 538

  Fly   337 RAIGLVLILACLLLMLLVRWRHH-----------HELPRNP------------------------ 366
            ..|....|...::|.|:.|:..:           .|.|..|
Zfish   539 MCIVFAYIGVSVVLFLVSRFSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNE 603

  Fly   367 --YYELLVLTMGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQT 427
              .:..|..::|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::
Zfish   604 FGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES 668

  Fly   428 ISEVLAQ----HFTIQLAEVNE----------ARILASLPELRPEQLVYLEGSELQSFPALAQQS 478
            ..::..|    :.|:......|          .::.:.:....|.  |:::.:: :....:.:..
Zfish   669 AEDLAKQTEIAYGTLDAGSTKEFFRRSKIAVFEKMWSYMKSADPS--VFVKTTD-EGVMRVRKSK 730

  Fly   479 GSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHG 543
            |..|.:...|..||....:....|.     |...:.::.......:.|.|...:|..:...:..|
Zfish   731 GKYAYLLESTMNEYIEQRKPCDTMK-----VGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQG 790

  Fly   544 FLEHWTRQY--------VSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVL 600
            .|:....::        ....|.||::.|                                   |
Zfish   791 LLDKLKNKWWYDKGECGSGGGDSKDKTSA-----------------------------------L 820

  Fly   601 SMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMKSDIKKQI--SKLVR 654
            |:..:|.:|:::: ..|| |::|.::|..   .|.|...|:||..|...:  |.|.|
Zfish   821 SLSNVAGVFYILI-GGLGLAMLVALVEFC---YKSRTESRRMKQSINDAMHCSTLTR 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	36/197 (18%)
		ANF_receptor	36..369	CDD:279440	32/179 (18%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	70/442 (16%)
		Lig_chan	536..836	CDD:278489	47/343 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930