Protein Alignment Ir7b and Grid2

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 606
• Identity: 123/606 - (20%)
• Similarity: 200/606 - (33%)
• Gaps: 212/606 - (34%)

  Fly   132 YGEEMQATLRFL--WR-LSVLN------------VGVVLRPPGDHILMVSYFPFSALHGCQVISA 181
            ||||:...:|.|  |. ::.||            .|||||     ::.|...||      .::|.
  Rat   405 YGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLR-----VVTVLEEPF------VMVSE 458

  Fly   182 NVV---NRYQVGTKRWASQDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVGIEGALLQF 243
            ||:   .:||     ..|.|...: |.|:.|.........|..|  ..|...|::.|:.|.|: |
  Rat   459 NVLGKPKKYQ-----GFSIDVLDA-LSNYLGFNYEIYVAPDHKY--GSPQEDGTWNGLVGELV-F 514

  Fly   244 MAENLNFTVGLYWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFM 308
            ...::..:......::|.|:           :....:.|:|:|
  Rat   515 KRADIGISALTITPDRENVV-----------DFTTRYMDYSVG---------------------- 546

  Fly   309 SHIMLVTNLQSAYSAYEKLSFPFTPLLWRAI-GLVLILACLLLMLLVRWRHHHELPRN------- 365
               :|:...:.....:..|: ||...||..| |.||::.  ||:.|:.|.:...|...
  Rat   547 ---VLLRRAEKTVDMFACLA-PFDLSLWACIAGTVLLVG--LLVYLLNWLNPPRLQMGSMTSTTL 605

  Fly   366 ------------------PYYELLVLTMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQSGM 412
                              ||..|....|.|    .|             ||||.:|: |.|.:.
  Rat   606 YNSMWFVYGSFVQQGGEVPYTTLATRMMMG----AW-------------WLFALIVI-SSYTAN- 651

  Fly   413 YQLLRQDTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPEL-RPEQLVYLEGSELQSFPALAQ 476
                               ||...||...|.:    :.||.:| :...:.|  |:.|.|  |:.|
  Rat   652 -------------------LAAFLTITRIESS----IQSLQDLSKQTDIPY--GTVLDS--AVYQ 689

  Fly   477 QSGSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQ--IQHA 539
            .    .|:..|.|:|                  |:.:|:|......|.:.....||..|  ||..
  Rat   690 H----VRMKGLNPFE------------------RDSMYSQMWRMINRSNGSENNVLESQAGIQKV 732

  Fly   540 HTHGFLEHW---TRQYVSAVDEKDESVARIASTSYSTLDGI---DGDP----------SLSESEE 588
            ....:...|   ..:|| |:::.|.|...:.:|......||   .|.|          .|.:| .
  Rat   733 KYGNYAFVWDAAVLEYV-AINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQS-G 795

  Fly   589 DQQV-------------------APVRQNVLSMRELAALFWLILWANLGAVVVFVLELLLPRIKL 634
            |..:                   |..:...|.::.||.:|.::....:.:.::.|||....|.|.
  Rat   796 DMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKG 860

  Fly   635 RKILRKMKSDIKKQISKLVRK 655
            .::..| :.|.:..:..|.|:
  Rat   861 SRVPSK-EDDKEIDLEHLHRR 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	9/23 (39%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	100/494 (20%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007