DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and grin2ab

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	457	Identity:	77/457 - (16%)
Similarity:	154/457 - (33%)	Gaps:	124/457 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 GSFV-----GIEGALLQFMAENLNFTVGLYWMNKEEVLATFDESGR--------IFDEIFGHHAD 282
            ||:|     |....:|:.:|.|:.||..||       |.|..:.|:        :..|:....|.
Zfish   437 GSYVKKCCKGFCIDILKKIARNVKFTYDLY-------LVTNGKHGKKINNVWNGMVGEVVYKKAV 494

  Fly   283 FSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILAC 347
            .::|...........|.:  |..:..:.|.::.:..:...:......||:..:|..:.::|::..
Zfish   495 MAVGSLTINEERSEAIDF--SVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVT 557

  Fly   348 LLLMLLVRW----RHHHEL-----PRNPYYEL--LVLTMGGNLEDRWVPQRFP----SRLVLLTW 397
            .:.:.|..:    ..:..|     |..|.:.:  .|..:.|.:.:..||.:.|    |:.::..|
Zfish   558 AIAVFLFEFISPLGFNRNLAQGKDPHGPSFTIGKAVWLLWGLVFNNSVPVQNPRGTTSKFIVSVW 622

  Fly   398 LFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPELRPEQLVY 462
            .|..::..:.|.:.:...:.|               :.|.                    :|:..
Zfish   623 AFFAVIFLASYTANLAAFMIQ---------------EEFV--------------------DQVTG 652

  Fly   463 LEGSELQSFPALAQQSGSSARVAILTPYEYFGYFR-KVHPMSRRLHLVRERIYTQQLAFYVRRHS 526
            |...:.||                  ||.|...|| ...|.......:|:. |.....:.|:.|.
Zfish   653 LSDRKFQS------------------PYSYSPPFRFGTVPNGSTERNIRKN-YPAMHQYMVKYHQ 698

  Fly   527 HLVGVLNK--QIQHAHTHGFL-EHWTRQYVSAVDEKDESVA-----RIASTSYS----------- 572
              .||::.  .::......|: :.....|::..|:..:.|.     ..|:|.|.
Zfish   699 --TGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFATTGYGIAMQKGSYWKR 761

  Fly   573 ----TLDGIDGDPSLSESEED-------QQVAPVRQNVLSMRELAALFWLILWANLGAVVVFVLE 626
                .:.||.||..:.|.|..       .:...|..:.|.:..:|.:|:::..|...:::.||.|
Zfish   762 LVDLAILGIIGDGEMEELEAQWLTGICHNEKNEVMSSQLDVDNMAGVFYMLAAAMALSLITFVWE 826

  Fly   627 LL 628
            .|
Zfish   827 HL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373
		ANF_receptor	48..358	CDD:279440
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	68/417 (16%)
		Lig_chan	544..816	CDD:278489	50/327 (15%)
		NMDAR2_C	827..1445	CDD:287527	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840