DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and GluRIID

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	139/767 - (18%)
Similarity:	246/767 - (32%)	Gaps:	238/767 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DLAEALAQVVANSEMGRF-------KTLYIYTHTNSQ---------------STGGHLEELL--- 64
            |:|.||..:|...|..||       :.|.|..|..::               :..|:.:.:|
  Fly   141 DIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRI 205

  Fly    65 ----DQVLMIVPNNLQARRLLLQQSM-----------------------EYKPYVHAVLALVDGL 102
                |..:::|.:......||.|...                       ||| |..   |.:.|:
  Fly   206 RKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYK-YSE---ANITGI 266

  Fly   103 PSLSAIYARIRATQDLSH-------------TLIYMSMPT--DAYGEEMQATLRFLWRLSVLNVG 152
            ...|.....:|...:..|             |.|.|.|..  ||.....:.|....::..:||..
  Fly   267 RMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCS 331

  Fly   153 V---VLRPPGD------HILMVS--------YFPFSALHG--CQVISANVVNRYQVGTKRWASQD 198
            .   .::|.|.      ..|.:.        ||..:...|  ..||........:|||  |....
  Fly   332 ERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGT--WEEGK 394

  Fly   199 YF----PSKLGNF------------YGCLLTCATWEDMPY--LVWRPD---GSGSFVGIEGALLQ 242
            .|    |.:..||            :..|::.||   .||  ||...|   |:..|.|....|::
  Fly   395 DFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVAT---KPYASLVESIDTLIGNNQFQGYGVDLIK 456

  Fly   243 FMAENL--NFT-------VGLYWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEI 298
            .:|:.|  |||       .|.:  ||     |.:.:..:..||....||.::............|
  Fly   457 ELADKLGFNFTFRDGGNDYGSF--NK-----TTNSTSGMLKEIVEGRADLAITDLTITSEREEVI 514

  Fly   299 PYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLL-----VRWRH 358
            .:| ..:..:...:|....|.|..|......||:..:|..:|:..:...|...::     :.|
  Fly   515 DFS-IPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEW-- 576

  Fly   359 HHELPRNPY------YEL---------LVLTMGGNLE--DRWVPQRFPSRLVLLTWLFATLVLRS 406
                 .|||      .||         |..|.|..|:  ....|:...:|.:...|.|.||::.|
  Fly   577 -----DNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVS 636

  Fly   407 GYQSGMYQLLRQDTQRNPPQTISEVLAQHFTIQLA--EVNEARILASLPELRPEQLVYLEGSE-L 468
            .|.:.:...|..:...:|..::.::......:|..  .....|...|    ..|:.:|::.:| |
  Fly   637 SYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFS----TSEEPIYIKMNEYL 697

  Fly   469 QSFPALAQQSGSSA--RVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGV 531
            .:.|.:..::....  :|...|.|.:.     :...|...:.|||...|:            ||
  Fly   698 NAHPEMLMENNQQGVDKVKSGTKYAFL-----MESTSIEFNTVRECNLTK------------VG- 744

  Fly   532 LNKQIQHAHTHGFLEHWTRQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVR 596
                                  ..:|||...:|.:.:..|..    ..:.:|.|.:|...:|.::
  Fly   745 ----------------------DPLDEKGYGIAMVKNWPYRD----KFNKALLELQEQGVLARLK 783

  Fly   597 Q--------------------NVLSMRELAALFWLILWANLGAVVVFVLELL 628
            .                    :.|.:..|:.::.:::   :|:::..::.:|
  Fly   784 NKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLV---IGSIISIIISIL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	48/261 (18%)
		ANF_receptor	46..380	CDD:279440	44/242 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	83/436 (19%)
		Lig_chan	549..819	CDD:278489	52/324 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840