DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and gria4a

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_999971.1	Gene:	gria4a / 407735	ZFINID:	ZDB-GENE-020125-7	Length:	898	Species:	Danio rerio

Alignment Length:	386	Identity:	76/386 - (19%)
Similarity:	136/386 - (35%)	Gaps:	102/386 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 FMS---HIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR---WRHHHELPR- 364
            |||   .||:....:|....:..|. |....:|..|....|...::|.|:.|   :..|.|.|.
Zfish   511 FMSLGISIMIKKPQKSKPGVFSFLD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEE 574

  Fly   365 -----------NPY--YELLVLTMGGNLED--RWVPQRFPSRLVLLTWLFATLVLRSGYQSGMYQ 414
                       |.:  :..|..::|..::.  .:.|:....|:|...|.|.||::.|.|.:.:..
Zfish   575 GSDGPPSDQPPNEFGIFNSLWFSLGAFMQQGCDFTPRSLSGRIVGGVWWFFTLIIISSYTANLAA 639

  Fly   415 LLRQDTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSG 479
            .|..:...:|.:: :|.||:...|....::                   .||..:.|
Zfish   640 FLTVERMVSPIES-AEDLAKQTEIAYGTLD-------------------SGSTKEFF-------- 676

  Fly   480 SSARVAILTPYE-YFGYFRKVHPMSRRLHLVRERIYTQQLA---FYVRRHSHLVGVLNKQIQHAH 540
            ..:::|:   || .:.|.:...|          .::|:..|   ..||:.......|.:...:.:
Zfish   677 RRSKIAV---YEKMWSYMKSAEP----------TVFTKTTAEGVARVRKSKGKYAFLLESTMNEY 728

  Fly   541 THGFLEHWTRQYVSAVDEKDESVARIASTSYST--------------LDGI---------DGDPS 582
            |.......|.:....:|.|...||....:...|              ||.:         :..|.
Zfish   729 TEQRKPCDTMKVGGNLDSKGYGVATPKGSQLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPK 793

  Fly   583 LSESEEDQQVAPVRQNVLSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
            .|.|::....|      ||:..:|.:|: ||...|| |::|.::|..   .|.|...:|:|
Zfish   794 DSGSKDKSSQA------LSLSNVAGVFY-ILVGGLGLAMLVALVEFC---YKSRAEAKKLK 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria4a	NP_999971.1	PBP1_iGluR_AMPA_GluR4	23..393	CDD:107383
		ANF_receptor	34..375	CDD:279440
		PBP2_iGluR_AMPA_GluR4	408..790	CDD:270445	57/320 (18%)
		Lig_chan	540..821	CDD:278489	59/328 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930