DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and gria3b

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	494	Identity:	88/494 - (17%)
Similarity:	172/494 - (34%)	Gaps:	115/494 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LTCATWEDMPYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GLYWMNKEEVLA 264
            :...|..:.||::::.     :|:..:.|....|...:|:::....       |.|.....|
Zfish   415 IVVTTIMEAPYVMYKKNHMHLEGNEKYEGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPE--- 476

  Fly   265 TFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEK 326
            |...:|.:.:.::| .||.::............|.:|:.   |||   .||:....:|....:..
Zfish   477 TKSWNGMVGELVYG-RADIAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQKSKPGVFSF 537

  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVRWRHHH------------ELPRNP-----YYELLVLT 374
            |. |....:|..|....|...::|.|:.|:..:.            :.|.:|     .:..|..:
Zfish   538 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFS 601

  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ--- 434
            :|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::..::..|
Zfish   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEI 666

  Fly   435 -HFTIQLAEVNE--ARILASLPELRPEQLVYLEGSELQSF-----PALAQQSGSSARVAIL---T 488
             :.|:......|  .|...::.|   :...|::.:|...|     ..:|:...|..:.|.|   |
Zfish   667 AYGTLDSGSTKEFFRRSKIAVYE---KMWSYMKSAEPSVFAKTTPDGVARVRKSKGKFAFLLEST 728

  Fly   489 PYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQY- 552
            ..||....:....|.     |...:.::.......:.|.|...:|..:...:..|.|:....::
Zfish   729 MNEYIEQRKPCDTMK-----VGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWW 788

  Fly   553 -------VSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFW 610
                   ....|.||::.|                                   ||:..:|.:|:
Zfish   789 YDKGECGSGGGDSKDKTSA-----------------------------------LSLSNVAGVFY 818

  Fly   611 LILWANLG-AVVVFVLELL------LPRIKLRKILRKMK 642
             ||...|| |::|.::|..      ..|:||.|..:..|
Zfish   819 -ILVGGLGLAMMVALIEFCYKSRAEAKRLKLEKNAQNYK 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141
		ANF_receptor	36..379	CDD:279440
		PBP2_iGluR_AMPA	412..794	CDD:270433	68/394 (17%)
		Lig_chan	544..824	CDD:278489	53/323 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840