DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and clumsy

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	106/547 - (19%)
Similarity:	194/547 - (35%)	Gaps:	127/547 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GEEMQATLRFLWRLSVLNVGVVLRPPGDHIL-MVSYFPFSALHGCQVISANVVNRYQVGTKRWAS 196
            |:....||||:    .||        .|..| :.::.|   ::|..|::.:..:..:||.|....
  Fly   366 GQRSFFTLRFM----ELN--------SDGFLDLATWDP---VNGLDVLNDDEESEKRVGQKLSNK 415

  Fly   197 QDYFPSKLGNFYGCLLTCATWEDMPYLVWRP-------DGSGSFVGIEGALLQFMAENLNFTV-- 252
            .....|:||              .|:|..|.       .|:..:.|....|:..:|:.|||..
  Fly   416 TFIVSSRLG--------------APFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEF 466

  Fly   253 -----GLYW-MNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHI 311
                 |.|. :||  |..|:|   .|..::...:||..:.......|....:.:   |..||:..
  Fly   467 RMSPDGKYGALNK--VTQTWD---GIVRQLIDGNADLGICDLTMTSSRRQAVDF---TPPFMTLG 523

  Fly   312 MLVTNLQSAYSAYEKLSF--PFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHELPRNPYYE 369
            :.:...:......:..||  ||:..:|..:|...:...|||..|.|     |.:.|........|
  Fly   524 ISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVE 588

  Fly   370 LLVLTMG------GNLEDRW---VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPP 425
            .:...|.      |:|..:.   :|:...:|||...|.|..|::.:.|.:.:...|....|.|
  Fly   589 NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQAN-- 651

  Fly   426 QTISEVLAQHFTIQLAEVNEARILASLPELR------PEQLVYLEGSELQSFPAL--AQQSGSSA 482
                            .:|.|..||:..:::      ...:.:...|...::..:  |.:|.|.
  Fly   652 ----------------SINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASP- 699

  Fly   483 RVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEH 547
              ::.|.....|    |..:.:..:|....:.:..|.:.|.|...||.:          .|:|::
  Fly   700 --SVFTKTNDEG----VERVQKGKNLYAFLMESTTLEYNVERKCDLVQI----------GGWLDY 748

  Fly   548 WT-----------RQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLS 601
            .:           |:.:||...|...:.::|.........:.|..:..:|:||....|    .|.
  Fly   749 KSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTP----ELG 809

  Fly   602 MRELAALFWLILWANLGAVVVFVLELL 628
            :..:..:|.::....|.|:|:...|.|
  Fly   810 LENVGGVFLVLGLGLLSAMVLGCTEFL 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	11/44 (25%)
		ANF_receptor	39..379	CDD:279440	5/16 (31%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	79/429 (18%)
		Lig_chan	548..812	CDD:278489	54/302 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840