DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and gria4b

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_997917.2	Gene:	gria4b / 336069	ZFINID:	ZDB-GENE-030131-8013	Length:	904	Species:	Danio rerio

Alignment Length:	698	Identity:	133/698 - (19%)
Similarity:	247/698 - (35%)	Gaps:	173/698 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVANSEMGRFKTLYI--YTHTNSQSTGGHLEELLDQVLMIVPNNLQARRLLLQQSMEY----KPY 91
            ::||  :| ||.:.:  :.|..:..||..|.:..:.:::    .|..|...|.| .||    .|.
Zfish   238 IMAN--LG-FKDINLERFMHGGANVTGFQLVDFSNPMVI----KLMQRWNKLDQ-REYPGSDAPP 294

  Fly    92 VHAVLALVDGLPSLSAIYARIRATQ-DLSHTLI---YMSMPTDAY--GEEMQATLRFLWRLSVLN 150
            .:......||:..::..:..:|..: |:|...|   .::.|...:  |.:|:.||:     .|..
Zfish   295 KYTSALTYDGVMVMAEAFRNLRRQKVDISRRGIAGDCLANPAAPWNQGIDMERTLK-----QVHL 354

  Fly   151 VGVVLRPPGDHILMVSYFPFSALHGCQV-ISANVVNRYQVGTKR---W-------ASQDY--FPS 202
            .|:......||            :|.:| .:.:|......|.:|   |       .:||:  .|:
Zfish   355 QGLTGNVQFDH------------YGRRVNYTMDVFELKSNGPRRIGYWNDADKLVLTQDHALLPN 407

  Fly   203 KLGNFYGCLLTCATWEDMPYLV----WRP-DGSGSFVGIEGALLQFMAENLNFTV-------GLY 255
            :........:...|..:.||::    |.. :|:..:.|....|...:|:::.|..       |.|
Zfish   408 ETSGMENRTVIVTTIMEGPYVMLKKNWEMYEGNEQYEGYCVDLASEIAKHIGFKYKISIVPDGKY 472

  Fly   256 WMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNL 317
            .....|   |...:|.:.:.::| .|:.::............|.:|:.   |||   .||:....
Zfish   473 GARDPE---TKIWNGMVGELVYG-KAEIAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQ 530

  Fly   318 QSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR---WRHHHELPR------------NPY 367
            :|....:..|. |....:|..|....|...::|.|:.|   :..|.|.|.            |.:
Zfish   531 KSKPGVFSFLD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEEGTDGLPSDQPPNEF 594

  Fly   368 --YELLVLTMGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTI 428
              :..|..::|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::
Zfish   595 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES- 658

  Fly   429 SEVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYE-Y 492
            :|.||:...|....::                   .||..:.|        ..:::|:   || .
Zfish   659 AEDLAKQTDIAYGTLD-------------------SGSTKEFF--------RRSKIAV---YEKM 693

  Fly   493 FGYFRKVHPMSRRLHLVRERIYTQQLA---FYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVS 554
            :.|.:...|          .::|:..|   ..||:.......|.:...:.:|.......|.:...
Zfish   694 WSYMKSAEP----------TVFTKTTAEGVARVRKSKGKYAFLLESTMNEYTEQRKPCDTMKVGG 748

  Fly   555 AVDEKDESVAR--------------IASTSYSTLD----------GIDGDPSLSESEEDQQVAPV 595
            .:|.|...||.              :.......||          |..|.....|.::..|
Zfish   749 NLDSKGYGVATPKGSQLRSAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGGEKDKSSQ---- 809

  Fly   596 RQNVLSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
               .||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
Zfish   810 ---ALSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRNEAKRMK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria4b	NP_997917.2	Periplasmic_Binding_Protein_Type_1	28..398	CDD:324556	37/184 (20%)
		PBP2_iGluR_AMPA_GluR4	414..793	CDD:270445	74/427 (17%)
		Lig_chan	546..827	CDD:306551	58/329 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840