DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and Gria4

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	130/704 - (18%)
Similarity:	250/704 - (35%)	Gaps:	163/704 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVANSEMGRFKTLYI--YTHTNSQSTGGHLEELLDQVLMIVPNNLQARRLLLQQSMEY----KPY 91
            ::||  :| ||.:.:  :.|..:..||..|.:....::    ..|..|...|.| .||    .|.
  Rat   238 IIAN--LG-FKDISLERFIHGGANVTGFQLVDFNTPMV----TKLMDRWKKLDQ-REYPGSETPP 294

  Fly    92 VHAVLALVDGLPSLSAIYARIRATQ-DLS---HTLIYMSMPTDAYGE--EMQATLRFLWRLSVLN 150
            .:......||:..::..:..:|..: |:|   :....::.|...:|:  :|:.||:.: |:..|.
  Rat   295 KYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQV-RIQGLT 358

  Fly   151 VGVVLRPPGDHILMVSYFPFSALHGCQV-ISANVVNRYQVGTKR---WASQDY------FPSKLG 205
            ..|..    ||            :|.:| .:.:|......|.::   |...|.      .|: ||
  Rat   359 GNVQF----DH------------YGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPT-LG 406

  Fly   206 NFYGCL----LTCATWEDMPYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GL 254
            |....:    :...|..:.||::::.     :|:..:.|....|...:|:::....       |.
  Rat   407 NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGK 471

  Fly   255 YWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTN 316
            |.....:   |...:|.:.:.::| .|:.::............|.:|:.   |||   .||:...
  Rat   472 YGARDAD---TKIWNGMVGELVYG-KAEIAIAPLTITLVREEVIDFSKP---FMSLGISIMIKKP 529

  Fly   317 LQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR---WRHHHELPR-----------NPY 367
            .:|....:..|. |....:|..|....|...::|.|:.|   :..|.|.|.           |.:
  Rat   530 QKSKPGVFSFLD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEF 593

  Fly   368 --YELLVLTMGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTI 428
              :..|..::|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::.
  Rat   594 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESA 658

  Fly   429 SEVLAQ----HFTIQLAEVNE--ARILASLPELRPEQLVYLEGSELQSF-----PALAQQSGSSA 482
            .::..|    :.|:......|  .|...::.|   :...|:..:|...|     ..:|:...|..
  Rat   659 EDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYE---KMWTYMRSAEPSVFTRTTAEGVARVRKSKG 720

  Fly   483 RVAIL---TPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGF 544
            :.|.|   |..||....:....|.     |...:.::.......:.|.|...:|..:...:..|.
  Rat   721 KFAFLLESTMNEYIEQRKPCDTMK-----VGGNLDSKGYGVATPKGSSLRNAVNLAVLKLNEQGL 780

  Fly   545 LEHWTRQY--------VSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLS 601
            |:....::        ....|.||::.|                                   ||
  Rat   781 LDKLKNKWWYDKGECGSGGGDSKDKTSA-----------------------------------LS 810

  Fly   602 MRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMKSDIKKQISKLVR 654
            :..:|.:|: ||...|| |::|.::|..   .|.|...::||....:.|....|
  Rat   811 LSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMKLTFSEAIRNKAR 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	37/184 (20%)
		ANF_receptor	39..380	CDD:279440	34/166 (20%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	68/396 (17%)
		Lig_chan	546..825	CDD:278489	55/322 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930