Protein Alignment Ir7b and Gria2

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 824
• Identity: 150/824 - (18%)
• Similarity: 254/824 - (30%)
• Gaps: 313/824 - (37%)

  Fly    25 DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLD-------QVLMIVPNNL------- 75
            ||..||..::...:..:|  .|:|......||   |:.:||       ||..|...|:
  Rat   131 DLKGALLSLIEYYQWDKF--AYLYDSDRGLST---LQAVLDSAAEKKWQVTAINVGNINNDKKDE 190

  Fly    76 ------------QARRLLLQ-----------------QSMEYKPYVHAVLALVDG-LPSLSAIYA 110
                        :.||::|.                 :.::...|:.|.|...|| |..:....|
  Rat   191 TYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255

  Fly   111 RIRATQ--DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSAL 173
            .:...|  |...:|:                .:|:.|.|.|.   ....||.|...:.|
  Rat   256 NVSGFQIVDYDDSLV----------------SKFIERWSTLE---EKEYPGAHTATIKY------ 295

  Fly   174 HGCQVISANVVNRYQVGTKRWAS---QDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVG 235
                 .||...:..||.|:.:.:   |....|:.||...||..       |.:.|     |..|.
  Rat   296 -----TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLAN-------PAVPW-----GQGVE 343

  Fly   236 IEGALLQFMAENL-------------NFTVGL------------YWM------------------ 257
            ||.||.|...|.|             |:|:.:            ||.
  Rat   344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   258 ----NKEEVLATFDESGRIF-----------DEIFGHHADFSLG-----GFHFKPS-AG------ 295
                ||..|:.|..||..:.           :...|:..|.:..     ||.:|.: .|
  Rat   409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473

  Fly   296 ------------SEIPYSQS-------------------TYYFMS---HIMLVTNLQSAYSAYEK 326
                        .|:.|.::                   :..|||   .||:....:|....:..
  Rat   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538

  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL----------PRNPY--YELLVLT 374
            |. |....:|..|....|...::|.|:.|     | |..|.          ..|.:  :..|..:
  Rat   539 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGRETQSSESTNEFGIFNSLWFS 601

  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFT 437
            :|..:....  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.:: :|.|::...
  Rat   602 LGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLSKQTE 665

  Fly   438 IQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPM 502
            |....::                   .||..:.|        ..:::|:..  :.:.|.|...|
  Rat   666 IAYGTLD-------------------SGSTKEFF--------RRSKIAVFD--KMWTYMRSAEP- 700

  Fly   503 SRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA------------ 555
                     .::.:..|..|.|      |...:.::|:   .||....:|:..
  Rat   701 ---------SVFVRTTAEGVAR------VRKSKGKYAY---LLESTMNEYIEQRKPCDTMKVGGN 747

  Fly   556 VDEKDESVARIASTSYST--------------LDGI-------DGDPSLSESEEDQQVAPVRQNV 599
            :|.|...:|....:|..|              ||.:       .|:....:|...:     :.:.
  Rat   748 LDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKE-----KTSA 807

  Fly   600 LSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
            ||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
  Rat   808 LSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMK 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	63/313 (20%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	71/431 (16%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877