back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and GRIN2D

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	552	Identity:	97/552 - (17%)
Similarity:	189/552 - (34%)	Gaps:	194/552 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 VGTKRWASQDY---FP--SKLGNFYGCL-----LTCATWEDMPYLVWRPDG--SGSFV------- 234
            ||:  |..|..   :|  |:.|.|...:     ||.||.|:.|:::..|..  ||:.:
Human   401 VGS--WEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR 463

  Fly   235 ----------------------GIEGALLQFMAENLNFTVGLYWMNKEEVLATFDESGRIFD--- 274
                                  |....:|:.:|..:.|:..||       |.|..:.|:..|
Human   464 SQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY-------LVTNGKHGKKIDGVW 521

  Fly   275 -----EIFGHHADFSLGGFHFKPSAGS----EIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFP 330
                 |:|...||.::|..........    .:|:.::.   :|.::..:|...:.||:.:   |
Human   522 NGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETG---ISVMVARSNGTVSPSAFLE---P 580

  Fly   331 FTPLLWRAIGLVLILACLLLMLLVRWRHHHELPRNPYYELL---------VLTMGGNLEDRW--- 383
            ::|.:|    :::.:.||.::.:..:...:..|.. |...|         ..|:|.::...|
Human   581 YSPAVW----VMMFVMCLTVVAVTVFIFEYLSPVG-YNRSLATGKRPGGSTFTIGKSIWLLWALV 640

  Fly   384 ----VPQRFP----SRLVLLTWLFATLVLRSGYQSGMYQLLRQ-----------DTQRNPPQTIS 429
                ||...|    |::::|.|.|..::..:.|.:.:...:.|           |.:...||
Human   641 FNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQ--- 702

  Fly   430 EVLAQHFTIQLAEV----NEARILASLPELR-----------PEQLVYLEGSELQSFPALAQQSG 479
               .|:..::...|    .|..|.::.|::.           .|.|..|:..:|.:|
Human   703 ---EQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAF-------- 756

  Fly   480 SSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSH---LVGVLNKQIQHAHT 541
                                             ||...:..|:.|...   ||.:.:.::.....
Human   757 ---------------------------------IYDAAVLNYMARKDEGCKLVTIGSGKVFATTG 788

  Fly   542 HGFLEH----WTRQYVSAV-----DEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQ 597
            :|...|    |.|....|:     |::.|.:.|:      .|.||..:..:.          |..
Human   789 YGIALHKGSRWKRPIDLALLQFLGDDEIEMLERL------WLSGICHNDKIE----------VMS 837

  Fly   598 NVLSMRELAALFWLILWANLGAVVVFVLELLL 629
            :.|.:..:|.:|:::|.|...:::||..|.|:
Human   838 SKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLV 869

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.