Protein Alignment Ir7b and GRIN2C

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 127/735 - (17%)
• Similarity: 247/735 - (33%)
• Gaps: 278/735 - (37%)

  Fly    58 GHLEELLDQVLMIVPNNLQARRLLLQQSMEYKPYVHAVLALVDGLPSLSAIYARIRATQDLSHTL 122
            ||        :.:|||       |...|.:..|....|     ||.|:.....|:...|.:...:
Human   249 GH--------VWLVPN-------LALGSTDAPPATFPV-----GLISVVTESWRLSLRQKVRDGV 293

  Fly   123 IYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGD-----------------HILMVSY--- 167
            ..:::...:|           ||    ..|.:..|.||                 |:|.|::
Human   294 AILALGAHSY-----------WR----QHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGR 343

  Fly   168 -FPFSALHGCQVISANVV----NRYQ----VGTKRWASQDYFPSKLGNFYGCL------------ 211
             |.||.  |..::...:|    ||::    ||  ||.            :|.|
Human   344 DFSFSP--GGYLVQPTMVVIALNRHRLWEMVG--RWE------------HGVLYMKYPVWPRYSA 392

  Fly   212 ----------LTCATWEDMPY-LVWRPD-GSGSFV----------------------------GI 236
                      ||.||.|:.|: :|..|| |:|..|                            |.
Human   393 SLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGF 457

  Fly   237 EGALLQFMAENLNFTVGLYWMNKEEVLATFDESGR--------IFDEIFGHHADFSLGGFHFKPS 293
            ...:|:.:|..:.|:..||       |.|..:.|:        :..|::...||.::|.......
Human   458 CIDILKKLARVVKFSYDLY-------LVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEE 515

  Fly   294 AGS----EIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLV 354
            ...    .:|:.::.   :|.::..:|...:.||:.:   |::|.:|    :::.:.||.::.:.
Human   516 RSEIVDFSVPFVETG---ISVMVARSNGTVSPSAFLE---PYSPAVW----VMMFVMCLTVVAIT 570

  Fly   355 RWRHHHELPRNPYYELL---------VLTMGGNLEDRWV-----------PQRFPSRLVLLTWLF 399
            .:...:..|.: |.:.|         ..|:|.::...|.           |:...|::::|.|.|
Human   571 VFMFEYFSPVS-YNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAF 634

  Fly   400 ATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHF---------------------------- 436
            ..::..:.|.:.:...:.|:...:....:|:..:.|.
Human   635 FAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQDQYPPF 699

  Fly   437 ---TIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRK 498
               |:.... .|..|.::..::....:.:.:.|...:..:|  :.||.|:
Human   700 RFGTVPNGS-TERNIRSNYRDMHTHMVKFNQRSVEDALTSL--KMGSEAQ--------------- 746

  Fly   499 VHPMSRRLHLVRERIYTQQLAFYVRRHSH---LVGVLNKQIQHAHTHGFL----EHWTRQYVSAV 556
              |:.|:|...   ||...:..|:.....   ||.:.:.::.....:|..    .||.|    |:
Human   747 --PVPRKLDAF---IYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKR----AI 802

  Fly   557 D------------EKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALF 609
            |            :|.|:|         .|.||      .::|:::    |..:.|.:..:|.:|
Human   803 DLALLQFLGDGETQKLETV---------WLSGI------CQNEKNE----VMSSKLDIDNMAGVF 848

  Fly   610 WLILWANLGAVVVFVLELLL 629
            :::|.|...|::||..|.|:
Human   849 YMLLVAMGLALLVFAWEHLV 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	37/185 (20%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	78/488 (16%)
		NMDAR2_C	866..>941	CDD:463148	1/3 (33%)