Protein Alignment Ir7b and GRIN2B

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_000825.2
• Gene: GRIN2B / 2904
• HGNCID: 4586
• Length: 1484
• Species: Homo sapiens
• Alignment Length: 841
• Identity: 140/841 - (16%)
• Similarity: 257/841 - (30%)
• Gaps: 313/841 - (37%)

  Fly    12 SLVASTMESSSDW--------------DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEE 62
            |::.:.|| ..||              |....:...:.||                 ..|..|||
Human   155 SVMLNIME-EYDWYIFSIVTTYFPGYQDFVNKIRSTIENS-----------------FVGWELEE 201

  Fly    63 LL---------DQVLMIVPNNLQARRLLLQQSMEYKPYVHAVLALVDGL---------PSLSA-- 107
            :|         |..:......||:..:||..:.|...|:..|...| ||         |||.|
Human   202 VLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVANSV-GLTGYGYTWIVPSLVAGD 265

  Fly   108 ---IYARIRATQDLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFP 169
               :.|      :....||.:|.....||  :.|.:|.       .:.::.....|.:...|:.|
Human   266 TDTVPA------EFPTGLISVSYDEWDYG--LPARVRD-------GIAIITTAASDMLSEHSFIP 315

  Fly   170 FSA-----LHGCQVISANVVNRYQV-----GTKRWASQDYFP----------------SKLGNFY 208
            ...     .|..::..:|::|||.:     |.....|:|.:.                .::|.
Human   316 EPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGK-- 378

  Fly   209 GCLLTCATWED----MPYLVW---------RPDGSGSFVGIEGA--------------------- 239
                    |:|    |.|.||         :.|...|.|.:|.|
Human   379 --------WKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVP 435

  Fly   240 ----------------------------LLQFMAENLNFTVGLYWMNKEEVLATFDESGR----- 271
                                        :|:.:::::.||..||       |.|..:.|:
Human   436 CQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLY-------LVTNGKHGKKINGT 493

  Fly   272 ---IFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTP 333
               :..|:....|..::|...........:.:  |..:..:.|.::.:..:...:......||:.
Human   494 WNGMIGEVVMKRAYMAVGSLTINEERSEVVDF--SVPFIETGISVMVSRSNGTVSPSAFLEPFSA 556

  Fly   334 LLWRAIGLVLILACLLLMLLV--------------RWRHHHELPRNPYYEL--LVLTMGGNLEDR 382
            .:|     |::...||::..|              |.......|..|.:.:  .:..:.|.:.:.
Human   557 DVW-----VMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNN 616

  Fly   383 WVPQRFP----SRLVLLTWLFATLVLRSGYQSGMYQLLRQD------------------------ 419
            .||.:.|    |::::..|.|..::..:.|.:.:...:.|:
Human   617 SVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPF 681

  Fly   420 ---------TQRNPPQTISEVLAQHFTIQLAEVNEARILASLPELRPEQLVY-----------LE 464
                     |:||.....:|:.|.........|::|  |.||...:.:..:|           .|
Human   682 RFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDA--LLSLKTGKLDAFIYDAAVLNYMAGRDE 744

  Fly   465 GSELQSFP------------ALAQQSGSSARV--AILTPYEYF--GYFRKVHP--MSRRLHLVRE 511
            |.:|.:..            |:.:.||...:|  |||   :.|  |...::..  ::...|..:.
Human   745 GCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAIL---QLFGDGEMEELEALWLTGICHNEKN 806

  Fly   512 RIYTQQL-------AFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQ--YVSAVDEKDESVARIA 567
            .:.:.||       .||:...:..:.::....:|      |.:|..:  ::.....|...|..|:
Human   807 EVMSSQLDIDNMAGVFYMLGAAMALSLITFICEH------LFYWQFRHCFMGVCSGKPGMVFSIS 865

  Fly   568 STSYSTLDGIDGDPSLSESEEDQQV--AP------VRQNVLSMRELAALFWLILWANLGAV 620
            ...||.:.|:       ..||.|.|  :|      ...|:|.:...|...     |||..|
Human   866 RGIYSCIHGV-------AIEERQSVMNSPTATMNNTHSNILRLLRTAKNM-----ANLSGV 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIN2B	NP_000825.2	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	51/276 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	60/418 (14%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:A7XY94	604..623		3/18 (17%)
		NMDAR2_C	840..1484	CDD:463148	21/93 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1074..1097
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1161..1194
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1301
		Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097	1292..1304
		PDZ-binding. /evidence=ECO:0000250	1482..1484