Protein Alignment Ir7b and GRIK5

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 777
• Identity: 145/777 - (18%)
• Similarity: 231/777 - (29%)
• Gaps: 325/777 - (41%)

  Fly    43 KTLYIYTHTNSQSTGGHLEELLDQVL--MIVPNNLQARRLLLQQSMEYKPYVHAVLALVDGLPSL 105
            :||.:....:|:.....|:|:.|..:  :|:..|.....|:|:::.|              |...
Human   186 ETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASE--------------LGMT 236

  Fly   106 SAIYARIRATQDL-----------SHTLIYMSM--PTDAYGEEMQATLRFLWRLSVLNVGVVLRP 157
            ||.|..|..|.|.           |..::..||  .:..:..|...:|...||.: ......|.|
Human   237 SAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWREN-CEASTYLGP 300

  Fly   158 PGDHILMVSYFPFSALHGCQVISA-NVVNRYQ-VGTKRWA--SQDYFP----------------- 201
            .....||     |.|:|  .|:|| ..:||.| :|.|..|  |.:.:|
Human   301 ALSAALM-----FDAVH--VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGL 358

  Fly   202 ---------------------------SKLGNFYG--CLLTCATWEDM----------------- 220
                                       .::|.:|.  .|...||..|:
Human   359 TGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTIL 423

  Fly   221 --PYLVWRPD-----GSGSFVGIEGALLQFMAENLNFTV-------GLY--------WMNKEEVL 263
              ||::.||:     |:..|.|....:|:.:||.|.|..       |||        |
Human   424 ENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSW------- 481

  Fly   264 ATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAY----SAY 324
                 :|.:.:.|....||.::..|.........|.:|:.   ||:  :.::.|...:    ..|
Human   482 -----TGMVGELINRQKADLAVAAFTITAEREKVIDFSKP---FMT--LGISILYRVHMGRKPGY 536

  Fly   325 EKLSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHELPR-------NPYYELLVLTMGG 377
            .....||:|.:|..:.|..:....:|.|..|     |.:.|...|       |.|      |:|.
Human   537 FSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQY------TLGN 595

  Fly   378 NLEDRW-------------VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTIS 429
            :|   |             :|:...:|.|...|...||::.|.|.:.
Human   596 SL---WFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTAN------------------ 639

  Fly   430 EVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFG 494
              ||...|:|..||                       .::|...||.|          |..||
Human   640 --LAAFLTVQRMEV-----------------------PVESADDLADQ----------TNIEY-- 667

  Fly   495 YFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSAVDEK 559
              ..:|..|........|..|     |.|..:::                   .::|....|...
Human   668 --GTIHAGSTMTFFQNSRYQT-----YQRMWNYM-------------------QSKQPSVFVKST 706

  Fly   560 DESVARIASTSY-----STLD----------------------GID---GDPSLSE--------- 585
            :|.:||:.::.|     ||::                      ||.   |.|...|
Human   707 EEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771

  Fly   586 -------------------SEEDQQVAPVRQNVLSMRELAALFWLILWANLGAVVVFVLELL 628
                               .|||.     |...|.|..:..:|.:::...:.||.|.|:|.:
Human   772 ENNRLEILKRKWWEGGRCPKEEDH-----RAKGLGMENIGGIFIVLICGLIIAVFVAVMEFI 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	46/236 (19%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	84/477 (18%)