Protein Alignment Ir7b and GRIK4

DIOPT Version :9

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001269399.1
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 123/682 - (18%)
• Similarity: 239/682 - (35%)
• Gaps: 175/682 - (25%)

  Fly    37 SEMGRFKTLYIYTHTNSQSTGGHLEELLDQVLMIVPNNL------------QARRLLLQQSMEYK 89
            :|:|.....|.|..||.:.:...::.|:|..:.|:..::            |:.....|::.::.
Human   232 AELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQENCDHV 296

  Fly    90 PYVHAVL--ALVDGLPSLSAIYARIRATQDLSHTLIYMSMPTDA-------YGEEMQATLRFLWR 145
            |:....|  ||:     ..|:||.:.|.|:|:.:......|...       :|..:...||.: .
Human   297 PFTGPALSSALL-----FDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMV-E 355

  Fly   146 LSVLNVGVVLRPPG---DHILMVSYFPFSALHGCQVISANVVNRYQVGTKRW-----ASQD---Y 199
            |..|...:.....|   ::.|.:..|..:...             |:|  :|     .|.|   |
Human   356 LEGLTGHIEFNSKGQRSNYALKILQFTRNGFR-------------QIG--QWHVAEGLSMDSHLY 405

  Fly   200 FPSKLGNFYGCLLTCATWEDMPYLVWR-----PDGSGSFVGIEGALLQFMAENLNFTV------- 252
            ..:.....:...|...|..:.|||:.:     .:|:..:.|....:|:.:||.|.|..
Human   406 ASNISDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGD 470

  Fly   253 GLYWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNL 317
            |:|.:  .|...|:  :|.: .|:....||.::.|..........|.:|:.   ||:  :.::.|
Human   471 GVYGV--PEANGTW--TGMV-GELIARKADLAVAGLTITAEREKVIDFSKP---FMT--LGISIL 525

  Fly   318 QSAY----SAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHELPRNPYYELLV- 372
            ...:    ..|.....||:|.:|..:.|..:....:|.|:.|     |...|...:. ...|||
Human   526 YRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQG-RCNLLVN 589

  Fly   373 -LTMGGNLEDRW-------------VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRN 423
             .::|.:|   |             .|:...:|.|...|...||::.|.|.:.:...|.......
Human   590 QYSLGNSL---WFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDV 651

  Fly   424 PPQTISEVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILT 488
            |.:::.: ||....|:...::..           ..:.:.:.|..|::..:
Human   652 PIESVDD-LADQTAIEYGTIHGG-----------SSMTFFQNSRYQTYQRM-------------- 690

  Fly   489 PYEYFGYFRKVHPMSRRLHLVRERIYTQQLAF---------YVRRHSHLVGVLNKQIQHAHTHGF 544
             :.|. |.::.....:.......|:.....||         |.:|:.:|..:          .|.
Human   691 -WNYM-YSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQI----------GGL 743

  Fly   545 LEHWTRQY-----VSAV--DEKDESVARIASTSYSTL------DGIDGDPSLSESEEDQQVAPVR 596
            |:  |:.|     |.:|  ||.|.::.::...:...:      :|     .....|||.     |
Human   744 LD--TKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEG-----GKCPKEEDH-----R 796

  Fly   597 QNVLSMRELAALFWLILWANLGAVVVFVLELL 628
            ...|.|..:..:|.:::...:.|:.:.:||.|
Human   797 AKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	33/188 (18%)
		ANF_receptor	43..382	CDD:279440	29/155 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	75/423 (18%)
		Lig_chan	547..816	CDD:278489	53/322 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840