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Protein Alignment Ir7b and GRIK2

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	694	Identity:	119/694 - (17%)
Similarity:	227/694 - (32%)	Gaps:	215/694 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MESSSDWDLAEALAQVVANS--------EMGRFKTLYIYTHTNSQSTGGHLEELLDQVLM----- 69
            :::.|.::|...:.|:.|::        ||.|.|..::....:.:...|.|::.|...:|
Human   189 IKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253

  Fly    70 ------------IVP----------------NNLQARRLLLQQSMEY-----KP----------- 90
                        :.|                .|.|...::.:.|||.     ||
Human   254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTT 318

  Fly    91 -------YVHAVLALVDGLPSLSAIYARIRATQDLSHTLIYMSMPTDAYGEEMQATLRFLWRLSV 148
                   .||.|...|...|.::....:....:.......:||:..:|:.|.:...:.|
Human   319 DAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITF------ 377

  Fly   149 LNVGVVLRPPGDHILMVSYFPFSALHGCQVISANVVNRYQVGTKRW---------ASQDYFPSKL 204
             |....||...|               ..|||.......::||  |         .||...|:.:
Human   378 -NKTNGLRTDFD---------------LDVISLKEEGLEKIGT--WDPASGLNMTESQKGKPANI 424

  Fly   205 -GNFYGCLLTCATWEDMPYLVWRPD-----GSGSFVGIEGALLQFMAENLNFTVGLYWMNKEEVL 263
             .:.....|...|..:.||::::..     |:..|.|....||:.::..|.||..:..:...:..
Human   425 TDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYG 489

  Fly   264 ATFDESGR---IFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAY---- 321
            |..|.:|:   :..|:..|.||.::.     |.|   |.|.:......|...:...:...|
Human   490 AQDDANGQWNGMVRELIDHKADLAVA-----PLA---ITYVREKVIDFSKPFMTLGISILYRKPN 546

  Fly   322 ----SAYEKLSFPFTPLLWRAIGLVLI-LACLLLMLL----VRWRHHHELPRNPYYELL------ 371
                ..:..|: |.:|.:|..|.|..: ::|:|.::.    ..|.:.|  |.||..:::
Human   547 GTNPGVFSFLN-PLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH--PCNPDSDVVENNFTL 608

  Fly   372 ----------VLTMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQ 426
                      ::..|..|    :|:...:|:|...|.|.||::.|.|.:.:...|..:...:|..
Human   609 LNSFWFGVGALMQQGSEL----MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPID 669

  Fly   427 TISEVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYE 491
            :..: ||:...|:...|.:.           ..:.:.:.|::.::..: ....||.|.::|....
Human   670 SADD-LAKQTKIEYGAVEDG-----------ATMTFFKKSKISTYDKM-WAFMSSRRQSVLVKSN 721

  Fly   492 YFGYFRKVHPMSRRLHLVRERIYTQQLAFYV---------RRHSHL------------------- 528
            ..|.               :|:.|...||.:         :|:.:|
Human   722 EEGI---------------QRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMG 771

  Fly   529 --------VGVLNKQIQHAHTHGFLEHWTRQYVSAVDEKDESVA 564
                    :.:|..| :....|...|.|.|......:|..|:.|
Human   772 SPYRDKITIAILQLQ-EEGKLHMMKEKWWRGNGCPEEESKEASA 814

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.