Protein Alignment Ir7b and GRIK1

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001317923.1
• Gene: GRIK1 / 2897
• HGNCID: 4579
• Length: 949
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 133/758 - (17%)
• Similarity: 250/758 - (32%)
• Gaps: 230/758 - (30%)

  Fly     6 YILSCCSLVASTMESSSDWDLAEALAQVVANSEMGR-----FKT-------LYIYTHTNSQSTGG 58
            |::..||...:          ||.|.|::....|..     |.|       |.:|.::....||.
Human   226 YVIFDCSHETA----------AEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGF 280

  Fly    59 HLEELLDQVLMIVPNNLQARRLLLQQSMEY-----KPYVHAVLALVDGLPSLSA--IYARIRATQ 116
            .|..:         :|.....::.:.|||.     :|..    .|:||:.:..|  :|..:....
Human   281 RLLNI---------DNPHVSSIIEKWSMERLQAPPRPET----GLLDGMMTTEAALMYDAVYMVA 332

  Fly   117 DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSALHGCQV-IS 180
            ..||....:::      ..:|......|||....:.::.....|.  :..:..|:..:|.:. ..
Human   333 IASHRASQLTV------SSLQCHRHKPWRLGPRFMNLIKEARWDG--LTGHITFNKTNGLRKDFD 389

  Fly   181 ANVVNRYQVGTKR------------------WASQ------DYFPSKLGNFYGCL----LTCATW 217
            .::::..:.||::                  |.|.      |....|..|....|    |...|.
Human   390 LDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTI 454

  Fly   218 EDMPYLVWRPD-----GSGSFVGIEGALLQFMAENLNFTV-------GLYWMNKEEVLATFDESG 270
            .:.||:::|..     |:..|.|....||:.::..|.|..       |.|....::     .|..
Human   455 LEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDK-----GEWN 514

  Fly   271 RIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAY--------SAYEKL 327
            .:..|:..|.||.::        |...|.|.:......|...:...:...|        ..:..|
Human   515 GMVKELIDHRADLAV--------APLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 571

  Fly   328 SFPFTPLLWRAIGLVLILACL----LLMLLVR-----WRHHHELPRNPYYELL------------ 371
            : |.:|.:|    :.::||||    :|.::.|     |.:.|  |.||..:::
Human   572 N-PLSPDIW----MYVLLACLGVSCVLFVIARFTPYEWYNPH--PCNPDSDVVENNFTLLNSFWF 629

  Fly   372 ----VLTMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVL 432
                ::..|..|    :|:...:|:|...|.|.||::.|.|.:.:...|..:...:|..:..: |
Human   630 GVGALMQQGSEL----MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD-L 689

  Fly   433 AQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSF------------PALAQQSGSSARVA 485
            |:...|:...|.:.           ..:.:.:.|::.::            .||.:.|....:..
Human   690 AKQTKIEYGAVRDG-----------STMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRV 743

  Fly   486 ILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVG--------------VLNKQI 536
            :.|.|........:..:::|      .....|:...:....:.||              :|..|
Human   744 LTTDYALLMESTSIEYVTQR------NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQ- 801

  Fly   537 QHAHTHGFLEHWTRQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLS 601
            :....|...|.|.|.                          :|.|     |||.:.|    :.|.
Human   802 EEGKLHMMKEKWWRG--------------------------NGCP-----EEDNKEA----SALG 831

  Fly   602 MRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMKS 643
            :..:..:| ::|.|.|. :|.|.:.|.:....|...|.:|.||
Human   832 VENIGGIF-IVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGKS 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIK1	NP_001317923.1	PBP1_iGluR_Kainate	38..431	CDD:380605	38/235 (16%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	71/411 (17%)