DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and GRID1

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_060021.1	Gene:	GRID1 / 2894	HGNCID:	4575	Length:	1009	Species:	Homo sapiens

Alignment Length:	256	Identity:	51/256 - (19%)
Similarity:	93/256 - (36%)	Gaps:	47/256 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 GCLLTCATWEDMPYLVWRPDGSGS---FVGIEGALLQFMAENLNFTVGLYWMNKEEVLATFDESG 270
            |..|...|..:.|:::...:..|.   :.|....:|..:|:.|.|        |.|:....|  |
Human   436 GLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGF--------KYEIYQAPD--G 490

  Fly   271 R------------IFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAYSA 323
            |            :..|:....||.::......|...|.:.:|: .|...|..:|:...:...|.
Human   491 RYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSK-RYMDYSVGILIKKPEEKISI 554

  Fly   324 YEKLSFPFTPLLWRAIGLVLILACLLLMLLVRWR----HHHELPR----NPYYELLVLTMGGNLE 380
            : .|..||...:|..|...:.:..:|:.:|.|.:    .....||    ...:..:.:..|.
Human   555 F-SLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGA--- 615

  Fly   381 DRWVPQRFPS-------RLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ 434
              :|.|...|       |:|:.:|...||::.|.|.:.:...|......||.:|..::..|
Human   616 --FVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQ 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		51/256 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387
		ANF_receptor	41..400	CDD:279440
		PBP2_iGluR_delta_1	436..806	CDD:270448	51/256 (20%)
		Lig_chan	564..841	CDD:278489	23/116 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	930..954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840