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Protein Alignment Ir7b and GRIA4

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	718	Identity:	138/718 - (19%)
Similarity:	258/718 - (35%)	Gaps:	191/718 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVANSEMGRFKTLYI--YTHTNSQSTGGHLEELLDQVLMIVPNNLQARRLLLQQSMEY----KPY 91
            ::||  :| ||.:.:  :.|..:..||..|.:.  ...|::  .|..|...|.| .||    .|.
Human   238 IIAN--LG-FKDISLERFIHGGANVTGFQLVDF--NTPMVI--KLMDRWKKLDQ-REYPGSETPP 294

  Fly    92 VHAVLALVDGLPSLSAIYARIRATQ-DLS---HTLIYMSMPTDAYGE--EMQATLRFLWRLSVLN 150
            .:......||:..::..:..:|..: |:|   :....::.|...:|:  :|:.||:.: |:..|.
Human   295 KYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQV-RIQGLT 358

  Fly   151 VGVVLRPPGDHILMVSYFPFSALHGCQV-ISANVVNRYQVGTKR---WASQDYF------PSKLG 205
            ..|..    ||            :|.:| .:.:|......|.::   |...|..      |: ||
Human   359 GNVQF----DH------------YGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDVPT-LG 406

  Fly   206 NFYGCL----LTCATWEDMPYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GL 254
            |....:    :...|..:.||::::.     :|:..:.|....|...:|:::....       |.
Human   407 NDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGK 471

  Fly   255 YWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTN 316
            |.....:   |...:|.:.:.::| .|:.::............|.:|:.   |||   .||:...
Human   472 YGARDAD---TKIWNGMVGELVYG-KAEIAIAPLTITLVREEVIDFSKP---FMSLGISIMIKKP 529

  Fly   317 LQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR---WRHHHELPR-----------NPY 367
            .:|....:..|. |....:|..|....|...::|.|:.|   :..|.|.|.           |.:
Human   530 QKSKPGVFSFLD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEF 593

  Fly   368 --YELLVLTMGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTI 428
              :..|..::|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::
Human   594 GIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES- 657

  Fly   429 SEVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYE-Y 492
            :|.||:...|....::                   .||..:.|        ..:::|:   || .
Human   658 AEDLAKQTEIAYGTLD-------------------SGSTKEFF--------RRSKIAV---YEKM 692

  Fly   493 FGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA-- 555
            :.|.|...|          .::|:..|..|.|      |...:.:.|.   .||....:|:..
Human   693 WTYMRSAEP----------SVFTRTTAEGVAR------VRKSKGKFAF---LLESTMNEYIEQRK 738

  Fly   556 ----------VDEKDESVARIASTSYST--------------LDGI---------DGDPSLSESE 587
                      :|.|...||....:|..|              ||.:         :..|..|.|:
Human   739 PCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSK 803

  Fly   588 EDQQVAPVRQNVLSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMKSDIKKQISK 651
            :       :.:.||:..:|.:|: ||...|| |::|.::|..   .|.|...::||....:.|..
Human   804 D-------KTSALSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMKLTFSEAIRN 857

  Fly   652 LVR 654
            ..|
Human   858 KAR 860

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.