DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir7b and GRIA3

DIOPT Version :10

Sequence 1:NP_572410.2 Gene:Ir7b / 31690 FlyBaseID:FBgn0029965 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_000819.4 Gene:GRIA3 / 2892 HGNCID:4573 Length:894 Species:Homo sapiens


Alignment Length:426 Identity:80/426 - (18%)
Similarity:150/426 - (35%) Gaps:101/426 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 SGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFP 330
            :|.:.:.::| .||.::............|.:|:.   |||   .||:....:|....:..|. |
Human   491 NGMVGELVYG-RADIAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQKSKPGVFSFLD-P 550

  Fly   331 FTPLLWRAIGLVLILACLLLMLLVR-----W--RHHHELPRNP-----------YYELLVLTMGG 377
            ....:|..|....|...::|.|:.|     |  ..::|.||:|           .:..|..::|.
Human   551 LAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGA 615

  Fly   378 NLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ----HF 436
            .::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::..::..|    :.
Human   616 FMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYG 680

  Fly   437 TIQLAEVNE--ARILASLPELRPEQLVYLEGSELQSF-----PALAQQSGSSARVAIL---TPYE 491
            |:......|  .|...::.|   :...|::.:|...|     ..:|:...|..:.|.|   |..|
Human   681 TLDSGSTKEFFRRSKIAVYE---KMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNE 742

  Fly   492 YFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQY---- 552
            |....:....|.     |...:.::.......:.|.|...:|..:...:..|.|:....::    
Human   743 YIEQRKPCDTMK-----VGGNLDSKGYGVATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDK 802

  Fly   553 ----VSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLIL 613
                ....|.||::.|                                   ||:..:|.:|: ||
Human   803 GECGSGGGDSKDKTSA-----------------------------------LSLSNVAGVFY-IL 831

  Fly   614 WANLG-AVVVFVLELLL------PRIKLRKILRKMK 642
            ...|| |::|.::|...      .|:||.|..:..|
Human   832 VGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFK 867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir7bNP_572410.2 None
GRIA3NP_000819.4 PBP1_iGluR_AMPA_GluR3 35..409 CDD:380610
PBP2_iGluR_AMPA 422..805 CDD:270433 60/326 (18%)
Blue background indicates that the domain is not in the aligned region.

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