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Protein Alignment Ir7b and GRIA2

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	824	Identity:	150/824 - (18%)
Similarity:	255/824 - (30%)	Gaps:	313/824 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLD-------QVLMIVPNNL------- 75
            ||..||..::...:..:|  .|:|......||   |:.:||       ||..|...|:
Human   131 DLKGALLSLIEYYQWDKF--AYLYDSDRGLST---LQAVLDSAAEKKWQVTAINVGNINNDKKDE 190

  Fly    76 ------------QARRLLLQ-----------------QSMEYKPYVHAVLALVDG-LPSLSAIYA 110
                        :.||::|.                 :.::...|:.|.|...|| |..:....|
Human   191 MYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255

  Fly   111 RIRATQ--DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSAL 173
            .:...|  |...:|:                .:|:.|.|.|.   ....||.|...:.|
Human   256 NVSGFQIVDYDDSLV----------------SKFIERWSTLE---EKEYPGAHTTTIKY------ 295

  Fly   174 HGCQVISANVVNRYQVGTKRWAS---QDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVG 235
                 .||...:..||.|:.:.:   |....|:.||...||..       |.:.|     |..|.
Human   296 -----TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLAN-------PAVPW-----GQGVE 343

  Fly   236 IEGALLQFMAENL-------------NFTVGL------------YWM------------------ 257
            ||.||.|...|.|             |:|:.:            ||.
Human   344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   258 ----NKEEVLATFDESGRIF-----------DEIFGHHADFSLG-----GFHFKPS-AG------ 295
                ||..|:.|..||..:.           :...|:..|.:..     ||.:|.: .|
Human   409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473

  Fly   296 ------------SEIPYSQS-------------------TYYFMS---HIMLVTNLQSAYSAYEK 326
                        .|:.|.::                   :..|||   .||:....:|....:..
Human   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538

  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL----------PRNPY--YELLVLT 374
            |. |....:|..|....|...::|.|:.|     | |..|.          ..|.:  :..|..:
Human   539 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGRETQSSESTNEFGIFNSLWFS 601

  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFT 437
            :|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.:: :|.|::...
Human   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLSKQTE 665

  Fly   438 IQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPM 502
            |....::                   .||..:.|        ..:::|:..  :.:.|.|...|
Human   666 IAYGTLD-------------------SGSTKEFF--------RRSKIAVFD--KMWTYMRSAEP- 700

  Fly   503 SRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA------------ 555
                     .::.:..|..|.|      |...:.::|:   .||....:|:..
Human   701 ---------SVFVRTTAEGVAR------VRKSKGKYAY---LLESTMNEYIEQRKPCDTMKVGGN 747

  Fly   556 VDEKDESVARIASTSYST--------------LDGI-------DGDPSLSESEEDQQVAPVRQNV 599
            :|.|...:|....:|..|              ||.:       .|:....:|...:     :.:.
Human   748 LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKE-----KTSA 807

  Fly   600 LSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
            ||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
Human   808 LSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMK 847

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.