DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and GRIA1

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	482	Identity:	85/482 - (17%)
Similarity:	170/482 - (35%)	Gaps:	114/482 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 EDMPYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GLYWMNKEEVLATFDESG 270
            || ||::.:.     :|:..:.|....|...:|:::.::.       |.|.....:..|.   :|
Human   426 ED-PYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAW---NG 486

  Fly   271 RIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFPFT 332
            .:.:.::| .||.::............|.:|:.   |||   .||:....:|....:..|. |..
Human   487 MVGELVYG-RADVAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQKSKPGVFSFLD-PLA 546

  Fly   333 PLLWRAIGLVLILACLLLMLLVR-----WRHHHELPR----------NPY--YELLVLTMGGNLE 380
            ..:|..|....|...::|.|:.|     | |..|...          |.:  :..|..::|..::
Human   547 YEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ 610

  Fly   381 DRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ----HFTIQ 439
            ...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::..::..|    :.|::
Human   611 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLE 675

  Fly   440 LAEVNE--ARILASLPELRPEQLVYLEGSELQSFPALAQQ--------SGSSARVAILTPYEYFG 494
            .....|  .|...::.|   :...|::.:|...|....::        .|..|.:...|..||..
Human   676 AGSTKEFFRRSKIAVFE---KMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIE 737

  Fly   495 YFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQY------- 552
            ..:....|.     |...:.::.......:.|.|...:|..:...:..|.|:....::
Human   738 QRKPCDTMK-----VGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGEC 797

  Fly   553 -VSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLILWAN 616
             ....|.||::.|                                   ||:..:|.:|:::: ..
Human   798 GSGGGDSKDKTSA-----------------------------------LSLSNVAGVFYILI-GG 826

  Fly   617 LG-AVVVFVLELLLPRIKLRKILRKMK 642
            || |::|.::|..   .|.|...::||
Human   827 LGLAMLVALIEFC---YKSRSESKRMK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385
		ANF_receptor	47..382	CDD:279440
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	68/388 (18%)
		Lig_chan	548..827	CDD:278489	51/323 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840