DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and Grin2a

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	203	Identity:	29/203 - (14%)
Similarity:	80/203 - (39%)	Gaps:	32/203 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 LLQFMAENLNFTVGLYWMNKEEVLATFDESGR--------IFDEIFGHHADFSLGGFHFKPSAGS 296
            :|:.::..:.||..||       |.|..:.|:        :..|:....|..::|..........
  Rat   463 ILKKLSRTVKFTYDLY-------LVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSE 520

  Fly   297 EIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVRW----R 357
            .:.:  |..:..:.|.::.:..:...:......||:..:|..:.::|::...:.:.:..:    .
  Rat   521 VVDF--SVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG 583

  Fly   358 HHHEL-----PRNPYYEL--LVLTMGGNLEDRWVPQRFP----SRLVLLTWLFATLVLRSGYQSG 411
            ::..|     |..|.:.:  .:..:.|.:.:..||.:.|    |::::..|.|..::..:.|.:.
  Rat   584 YNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 648

  Fly   412 MYQLLRQD 419
            :...:.|:
  Rat   649 LAAFMIQE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	29/203 (14%)
		HisJ	<458..>541	CDD:223904	13/86 (15%)
		Glutamate binding. /evidence=ECO:0000269\|PubMed:16281028, ECO:0007744\|PDB:2A5S, ECO:0007744\|PDB:2A5T, ECO:0007744\|PDB:4NF4, ECO:0007744\|PDB:4NF8, ECO:0007744\|PDB:5I56, ECO:0007744\|PDB:5I57, ECO:0007744\|PDB:5I58, ECO:0007744\|PDB:5I59, ECO:0007744\|PDB:5JTY	511..513		0/1 (0%)
		Lig_chan	556..828	CDD:278489	14/101 (14%)
		Pore-forming. /evidence=ECO:0000250\|UniProtKB:B7ZSK1	599..620		3/20 (15%)
		Glutamate binding. /evidence=ECO:0000269\|PubMed:16281028, ECO:0000269\|PubMed:24462099, ECO:0007744\|PDB:2A5S, ECO:0007744\|PDB:2A5T, ECO:0007744\|PDB:4NF4, ECO:0007744\|PDB:4NF8	689..690
		Glutamate binding. /evidence=ECO:0000269\|PubMed:16281028, ECO:0000269\|PubMed:24462099, ECO:0007744\|PDB:2A5S, ECO:0007744\|PDB:2A5T, ECO:0007744\|PDB:4NF4, ECO:0007744\|PDB:4NF8	730..731
		NMDAR2_C	839..1464	CDD:287527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840