Protein Alignment Ir7b and Grik5

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 777
• Identity: 144/777 - (18%)
• Similarity: 230/777 - (29%)
• Gaps: 325/777 - (41%)

  Fly    43 KTLYIYTHTNSQSTGGHLEELLDQVL--MIVPNNLQARRLLLQQSMEYKPYVHAVLALVDGLPSL 105
            :||.:....:|:.....|:|:.|..:  :|:..|.....|:|:::.|              |...
  Rat   186 ETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASE--------------LGMT 236

  Fly   106 SAIYARIRATQDL-----------SHTLIYMSM--PTDAYGEEMQATLRFLWRLSVLNVGVVLRP 157
            ||.|..|..|.|.           |..::..||  .:..:..|...:|...||.: ........|
  Rat   237 SAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWREN-CEASTYPGP 300

  Fly   158 PGDHILMVSYFPFSALHGCQVISA-NVVNRYQ-VGTKRWA--SQDYFP----------------- 201
            .....||     |.|:|  .|:|| ..:||.| :|.|..|  |.:.:|
  Rat   301 ALSAALM-----FDAVH--VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGL 358

  Fly   202 ---------------------------SKLGNFYG--CLLTCATWEDM----------------- 220
                                       .::|.:|.  .|...||..|:
  Rat   359 TGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTIL 423

  Fly   221 --PYLVWRPD-----GSGSFVGIEGALLQFMAENLNFTV-------GLY--------WMNKEEVL 263
              ||::.||:     |:..|.|....:|:.:||.|.|..       |||        |
  Rat   424 ENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSW------- 481

  Fly   264 ATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAY----SAY 324
                 :|.:.:.|....||.::..|.........|.:|:.   ||:  :.::.|...:    ..|
  Rat   482 -----TGMVGELINRQKADLAVAAFTITAEREKVIDFSKP---FMT--LGISILYRVHMGRKPGY 536

  Fly   325 EKLSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHELPR-------NPYYELLVLTMGG 377
            .....||:|.:|..:.|..:....:|.|..|     |.:.|...|       |.|      |:|.
  Rat   537 FSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQY------TLGN 595

  Fly   378 NLEDRW-------------VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTIS 429
            :|   |             :|:...:|.|...|...||::.|.|.:.
  Rat   596 SL---WFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTAN------------------ 639

  Fly   430 EVLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFG 494
              ||...|:|..||                       .::|...||.|          |..||
  Rat   640 --LAAFLTVQRMEV-----------------------PVESADDLADQ----------TNIEY-- 667

  Fly   495 YFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSAVDEK 559
              ..:|..|........|..|     |.|..:::                   .::|....|...
  Rat   668 --GTIHAGSTMTFFQNSRYQT-----YQRMWNYM-------------------QSKQPSVFVKST 706

  Fly   560 DESVARIASTSY-----STLD----------------------GID---GDPSLSE--------- 585
            :|.:||:.::.|     ||::                      ||.   |.|...|
  Rat   707 EEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQ 771

  Fly   586 -------------------SEEDQQVAPVRQNVLSMRELAALFWLILWANLGAVVVFVLELL 628
                               .|||.     |...|.|..:..:|.:::...:.||.|.|:|.:
  Rat   772 ENNRLEILKRKWWEGGRCPKEEDH-----RAKGLGMENIGGIFVVLICGLIIAVFVAVMEFI 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	45/236 (19%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	84/477 (18%)