DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and Grin3a

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	105/492 - (21%)
Similarity:	182/492 - (36%)	Gaps:	153/492 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSALH--GCQVISANVVNRYQVGT---KRWASQDY 199
            |...|.||  .|.::|.||  ..|:::..|.|:.|  .||::. .:.:..:||.   :.|.:...
  Rat     4 LSLWWLLS--RVCLLLPPP--CALVLAGVPSSSSHPQPCQILK-RIGHAVRVGAVHLQPWTTAPR 63

  Fly   200 FPSKL--GNFYGCLLTCATWEDMPYLVWR-------------------PDGS---GSFVGIE--- 237
            ..|:.  |...|     |..:|.....||                   |.||   |...|.|
  Rat    64 AASRAQEGGRAG-----AQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLW 123

  Fly   238 --GALLQFMAENLNFTVGL--YWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEI 298
              .||| |..||||...||  |.::.|.|:|.  |:|              ||.....|.:....
  Rat   124 PRDALL-FAVENLNRVEGLLPYNLSLEVVMAI--EAG--------------LGDLPLMPFSSPSS 171

  Fly   299 PYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVRWRHHH 360
            |:|...:.|:.   |.::|..:.:.      |:||.:......:.||..:..:.::.:||    |
  Rat   172 PWSSDPFSFLQSVCHTVVVQGVSAL------LAFPQSQGEMMELDLVSSVLHIPVLSIVR----H 226

  Fly   361 ELPR---NPYYELLVLTMGGNLE---DRWVPQRFPSRLVLLTWL-FATLVLRSGYQSGMYQLLRQ 418
            |.||   ||.:  |.|::..:|.   |..|     |.|.:..|. |:.|:.:..:....:.||.:
  Rat   227 EFPRESQNPLH--LQLSLENSLSSDADVTV-----SILTMNNWYNFSLLLCQEDWNITDFLLLTE 284

  Fly   419 DTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPELRPEQL------VYLEGSELQSFPALAQQ 477
            :..:...:::..:        .|.::..:.|.|..:::.:.:      :.:.|.::.|...:.:.
  Rat   285 NNSKFHLESVINI--------TANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEM 341

  Fly   478 SGSSARVAILTPYEYFGYFRKVHPMSRRLHLVR------ERIYTQQLAFYVRRHSHLVGVLNKQI 536
            |....    |:|.|              ||.|.      |.:.|:.|.         :|::
  Rat   342 STQFG----LSPPE--------------LHWVLGDSQNVEELRTEGLP---------LGLI---- 375

  Fly   537 QHAH---THGFLEHWTRQYVSAVDEKDESVARIASTS 570
              ||   |....|::       |.:..|.|||..:|:
  Rat   376 --AHGKTTQSVFEYY-------VQDAMELVARAVATA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	95/462 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117		11/61 (18%)
		ANF_receptor	127..469	CDD:279440	75/359 (21%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438
		Lig_chan	676..942	CDD:278489
		PPP2CB binding site	951..987
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840