DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and glr-7

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	100/579 - (17%)
Similarity:	179/579 - (30%)	Gaps:	222/579 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 SKLGNFYGCL---------LTCATWEDMPYLVWRPDGSGSFVGIEGALLQFMAENLNFTVGLYWM 257
            |||...||.|         ....|....|::....|....:.|....|:..:...:|||..:|.:
Worm   355 SKLSVMYGTLQVDVRNLNIFRVVTLIQPPFVQRTGDPDTPYEGYCIDLINMIQVEVNFTYTIYEV 419

  Fly   258 NKEEVLATFDESGR---IFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQS 319
             ::....|.|::|.   :...:....||.:|..........:::.::...|..:...:|:.....
Worm   420 -EDGSFGTMDDNGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTILMKKADV 483

  Fly   320 AYSAY---EKLSFPFTPLLWRAIGLVLILACLLLMLLVRW----------RHHHELPRNPY---- 367
            .||.:   :.|.:|    :|..|....:...:||.:..|:          |:.:::.:..:
Worm   484 EYSLFKFMKVLEWP----VWLCIVAAYLFTSILLWIFDRFSPYSFTNNKERYQNDIEKRQFSLKE 544

  Fly   368 ---YELLVLTMGGNLEDRWVPQRFPSRLVLLT-WLFATLVLRSGYQSGMYQLLRQDTQRNPPQTI 428
               :.:..||..|..|   .|:....|||..| |||..:::.| |.:.:...|.......|..::
Worm   545 CLWFCMTSLTPQGGGE---APKNISGRLVAATWWLFGFIIIAS-YTANLAAFLTVSRLEQPISSL 605

  Fly   429 SEVLAQHFTIQ---------------LAEVNEA-------------------------------- 446
            .: ||:.:.|:               :||:.|.
Worm   606 DD-LAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVWDYPVSDK 669

  Fly   447 ----------------------RIL-----------------ASLPELRPEQLVYLEGSELQSFP 472
                                  |:|                 |:|.....:|:    |:|....|
Worm   670 FTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCNLQQV----GTEFSRKP 730

  Fly   473 -ALAQQSG-------SSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLV 529
             |:|.|||       |||.:.:|.              .|||..::|:.:|..
Worm   731 YAIAVQSGHILKDKISSAILMLLN--------------ERRLETLKEKWWTDN------------ 769

  Fly   530 GVLNKQIQHAHTHGFLEHWTRQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAP 594
              .||                  ||..|..|||            |||
Worm   770 --PNK------------------VSCPDSSDES------------DGI----------------- 785

  Fly   595 VRQNVLSMRELAALFWLILWANLGAVVVFVLELLLPRIKLRKILRKMKSDIKKQISKLV 653
                  |::.:..:|.:||.....::|....|....:.|.||...|.:.:::.:.|:.|
Worm   786 ------SIQNIGGVFIVILAGIALSIVTLAFEYYYYKRKARKAAEKEQEELEMKQSQQV 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	70/421 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910