DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and Grin3b

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	86/460 - (18%)
Similarity:	149/460 - (32%)	Gaps:	144/460 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 LLQFMAENLNFTVGLYWMNKEEVLATFDESGR---IFDEIFGHHADFSLGGFHFKPSAGSEIPYS 301
            ||:.:||:|.|...||.:...:..|..|  ||   :..::....|..::..|....:....:.::
  Rat   483 LLERLAEDLAFDFELYIVGDGKYGALRD--GRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFT 545

  Fly   302 QSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVRWRHHHEL-PR- 364
            ..  :|.:.:.::...:...|......:|....:|..:...|.|..|.| .|..||..:.| ||
  Rat   546 SP--FFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFL-TLYEWRSPYGLTPRG 607

  Fly   365 -------------NPYYELLVLTMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLL 416
                         |..|.:|.    |.......|:....|.::..|....|::.|.|.:.:..::
  Rat   608 RNRGTVFSYSSALNLCYAILF----GRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVM 668

  Fly   417 RQDTQRNPPQTISEVLAQH------------FTIQLAEVNEARILASLPELR-----------PE 458
            ..|      :|..|:...|            |........||.|.||.||:.           |.
  Rat   669 VGD------KTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPH 727

  Fly   459 QLVYL--EGSELQSF----PALAQQSGSSARVAILT---PYEYFGYFRKVHPMSRRLHLVRERIY 514
            .:..|  :..:|.:|    ..|..:....|...:||   |:...||         .:.|.:....
  Rat   728 GVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGY---------GIGLPQNSPL 783

  Fly   515 TQQLAFYVRRHSHLVGVLNKQIQHAHTHGFL----EHWTR-----QYVSAVDEKDESVARIASTS 570
            |..|:.::.|:.              :.||:    :.|.:     :.|.||.|
  Rat   784 TSNLSEFISRYK--------------SSGFIDLLHDKWYKMVPCGKRVFAVTE------------ 822

  Fly   571 YSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLI-------LWANLGAVVVFVLELL 628
              ||.                        :.:...:.||.|:       |..:||..|.:  .|:
  Rat   823 --TLQ------------------------MGVYHFSGLFVLLCLGLGSALLTSLGEHVFY--RLV 859

  Fly   629 LPRIK 633
            ||||:
  Rat   860 LPRIR 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	67/362 (19%)
		Lig_chan	576..842	CDD:278489	60/337 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840