DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and gria2a

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	559	Identity:	104/559 - (18%)
Similarity:	195/559 - (34%)	Gaps:	122/559 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 DAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSALHGCQVISANVVNRYQVGTKRW 194
            |.||..:..|:..   :.:.|.|.|         .:.|:             |.:::..| ||
Zfish   357 DQYGRRVNYTVNV---MELKNSGPV---------KIGYW-------------NEMDKMAV-TK-- 393

  Fly   195 ASQDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDG-----SGSFVGIEGALLQFMAENLNFTV-- 252
              .|.||:.........:...|..:.||::.:.:.     :..:.|....|...:|::..|..
Zfish   394 --SDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAELFTDNERYEGYCVDLAAEIAKHCGFKYQL 456

  Fly   253 -----GLYWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS--- 309
                 |.|.....|   |...:|.:.:.::| .||.::............|.:|:.   |||
Zfish   457 RIVADGKYGARDAE---TKIWNGMVGELVYG-KADIAVAPLTITLVREEVIDFSKP---FMSLGI 514

  Fly   310 HIMLVTNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL------- 362
            .||:....:|....:..|. |....:|..|....|...::|.|:.|     | |..|.
Zfish   515 SIMIKKPQKSKPGVFSFLD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGQLGP 577

  Fly   363 --PRNPY--YELLVLTMGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQ 421
              ..|.:  :..|..::|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:..
Zfish   578 SESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 642

  Fly   422 RNPPQTISEVLAQ----HFTIQLAEVNEARILASLPELRPEQLVYLEGSE--------LQSFPAL 474
            .:|.::..::..|    :.|:......|. ...|...|..:...|::.:|        ::....:
Zfish   643 VSPIESAEDLAKQTEIAYGTLDAGSTKEF-FRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRV 706

  Fly   475 AQQSGSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHA 539
            .:..|..|.:...|..||....:....|.     |...:.::.......:.|.|...:|..:...
Zfish   707 RKSKGKYAYLLESTMNEYIEQRKPCDTMK-----VGGNLDSKGYGIATPKGSALRNAVNLAVLKL 766

  Fly   540 HTHGFLEHWTRQYVSAVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRE 604
            :..|.|:....::..   :|.|.             |..|    .||:|       :.:.||:..
Zfish   767 NEQGLLDKLKNKWWY---DKGEC-------------GSGG----GESKE-------KTSALSLSN 804

  Fly   605 LAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
            :|.:|: ||...|| |::|.::|..   .|.|...::||
Zfish   805 VAGVFY-ILVGGLGLAMLVALVEFC---YKSRAEAKRMK 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	9/58 (16%)
		ANF_receptor	51..373	CDD:279440	4/18 (22%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	67/394 (17%)
		Lig_chan	538..816	CDD:278489	55/312 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840