DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and Grid2

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	739	Identity:	150/739 - (20%)
Similarity:	240/739 - (32%)	Gaps:	267/739 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SSSDWDLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLDQVLMIV---PNNLQARRLL 81
            |||..|..:..||   |.|:   ..||||                |.||::.   ...|:.|:..
Mouse   306 SSSLCDPKDPFAQ---NMEI---SNLYIY----------------DTVLLLANAFHKKLEDRKWH 348

  Fly    82 LQQSM-----EYKPYVHAVLAL-------VDGLPSLSAIYARIRATQDL------SHTLIYMSMP 128
            ...|:     ..||:......|       |:||            |.||      .:..::..:.
Mouse   349 SMASLSCIRKNSKPWQGGRSMLETIKKGGVNGL------------TGDLEFGENGGNPNVHFEIL 401

  Fly   129 TDAYGEEMQATLRFL--WR-LSVLN------------VGVVLRPPGDHILMVSYFPFSALHGCQV 178
            ...||||:...:|.|  |. ::.||            .|||||     ::.|...||      .:
Mouse   402 GTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLR-----VVTVLEEPF------VM 455

  Fly   179 ISANVV---NRYQVGTKRWASQDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVGIEGAL 240
            :|.||:   .:||     ..|.|...: |.|:.|.........|..|  ..|...|::.|:.|.|
Mouse   456 VSENVLGKPKKYQ-----GFSIDVLDA-LSNYLGFNYEIYVAPDHKY--GSPQEDGTWNGLVGEL 512

  Fly   241 LQFMAENLNFTVGLYWMNKEEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTY 305
            : |...::..:......::|.|:           :....:.|:|:|
Mouse   513 V-FKRADIGISALTITPDRENVV-----------DFTTRYMDYSVG------------------- 546

  Fly   306 YFMSHIMLVTNLQSAYSAYEKLSFPFTPLLWRAI-GLVLILACLLLMLLVRWRHHHELPRN---- 365
                  :|:...:.....:..|: ||...||..| |.||::.  ||:.|:.|.:...|...
Mouse   547 ------VLLRRAEKTVDMFACLA-PFDLSLWACIAGTVLLVG--LLVYLLNWLNPPRLQMGSMTS 602

  Fly   366 ---------------------PYYELLVLTMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQ 409
                                 ||..|....|.|    .|             ||||.:|: |.|.
Mouse   603 TTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG----AW-------------WLFALIVI-SSYT 649

  Fly   410 SGMYQLLRQDTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPEL-RPEQLVYLEGSELQSFPA 473
            :.                    ||...||...|.:    :.||.:| :...:.|  |:.|.|  |
Mouse   650 AN--------------------LAAFLTITRIESS----IQSLQDLSKQTDIPY--GTVLDS--A 686

  Fly   474 LAQQSGSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQ--I 536
            :.|.    .|:..|.|:|                  |:.:|:|......|.:.....||..|  |
Mouse   687 VYQH----VRMKGLNPFE------------------RDSMYSQMWRMINRSNGSENNVLESQAGI 729

  Fly   537 QHAHTHGFLEHW---TRQYVSAVDEKDESVARIASTSYSTLDGI---DGDP----------SLSE 585
            |......:...|   ..:|| |:::.|.|...:.:|......||   .|.|          .|.:
Mouse   730 QKVKYGNYAFVWDAAVLEYV-AINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQ 793

  Fly   586 SEEDQQV-------------------APVRQNVLSMRELAALFWLILWANLGAVVVFVLELLLPR 631
            | .|..:                   |..:...|.::.||.:|.::....:.:.::.|||....|
Mouse   794 S-GDMDILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSR 857

  Fly   632 IKLRKILRKMKSDIKKQISKLVRK 655
            .|..::..| :.|.:..:..|.|:
Mouse   858 RKGSRVPSK-EDDKEIDLEHLHRR 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		16/60 (27%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	36/156 (23%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	100/494 (20%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840