DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and Gria2

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	824	Identity:	150/824 - (18%)
Similarity:	255/824 - (30%)	Gaps:	313/824 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLD-------QVLMIVPNNL------- 75
            ||..||..::...:..:|  .|:|......||   |:.:||       ||..|...|:
Mouse   131 DLKGALLSLIEYYQWDKF--AYLYDSDRGLST---LQAVLDSAAEKKWQVTAINVGNINNDKKDE 190

  Fly    76 ------------QARRLLLQ-----------------QSMEYKPYVHAVLALVDG-LPSLSAIYA 110
                        :.||::|.                 :.::...|:.|.|...|| |..:....|
Mouse   191 TYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGA 255

  Fly   111 RIRATQ--DLSHTLIYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPGDHILMVSYFPFSAL 173
            .:...|  |...:|:                .:|:.|.|.|.   ....||.|...:.|
Mouse   256 NVSGFQIVDYDDSLV----------------SKFIERWSTLE---EKEYPGAHTATIKY------ 295

  Fly   174 HGCQVISANVVNRYQVGTKRWAS---QDYFPSKLGNFYGCLLTCATWEDMPYLVWRPDGSGSFVG 235
                 .||...:..||.|:.:.:   |....|:.||...||..       |.:.|     |..|.
Mouse   296 -----TSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLAN-------PAVPW-----GQGVE 343

  Fly   236 IEGALLQFMAENL-------------NFTVGL------------YWM------------------ 257
            ||.||.|...|.|             |:|:.:            ||.
Mouse   344 IERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDT 408

  Fly   258 ----NKEEVLATFDESGRIF-----------DEIFGHHADFSLG-----GFHFKPS-AG------ 295
                ||..|:.|..||..:.           :...|:..|.:..     ||.:|.: .|
Mouse   409 SGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGA 473

  Fly   296 ------------SEIPYSQS-------------------TYYFMS---HIMLVTNLQSAYSAYEK 326
                        .|:.|.::                   :..|||   .||:....:|....:..
Mouse   474 RDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 538

  Fly   327 LSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHEL----------PRNPY--YELLVLT 374
            |. |....:|..|....|...::|.|:.|     | |..|.          ..|.:  :..|..:
Mouse   539 LD-PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HTEEFEDGRETQSSESTNEFGIFNSLWFS 601

  Fly   375 MGGNLEDRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFT 437
            :|..::...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.:: :|.|::...
Mouse   602 LGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLSKQTE 665

  Fly   438 IQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPM 502
            |....::                   .||..:.|        ..:::|:..  :.:.|.|...|
Mouse   666 IAYGTLD-------------------SGSTKEFF--------RRSKIAVFD--KMWTYMRSAEP- 700

  Fly   503 SRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQYVSA------------ 555
                     .::.:..|..|.|      |...:.::|:   .||....:|:..
Mouse   701 ---------SVFVRTTAEGVAR------VRKSKGKYAY---LLESTMNEYIEQRKPCDTMKVGGN 747

  Fly   556 VDEKDESVARIASTSYST--------------LDGI-------DGDPSLSESEEDQQVAPVRQNV 599
            :|.|...:|....:|..|              ||.:       .|:....:|...:     :.:.
Mouse   748 LDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKE-----KTSA 807

  Fly   600 LSMRELAALFWLILWANLG-AVVVFVLELLLPRIKLRKILRKMK 642
            ||:..:|.:|: ||...|| |::|.::|..   .|.|...::||
Mouse   808 LSLSNVAGVFY-ILVGGLGLAMLVALIEFC---YKSRAEAKRMK 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	63/313 (20%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	71/431 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930