back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and Gria1

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001106796.1	Gene:	Gria1 / 14799	MGIID:	95808	Length:	907	Species:	Mus musculus

Alignment Length:	479	Identity:	86/479 - (17%)
Similarity:	172/479 - (35%)	Gaps:	108/479 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 EDMPYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GLYWMNKEEVLATFDESG 270
            || ||::.:.     :|:..:.|....|...:|:::.::.       |.|.....:..|.   :|
Mouse   416 ED-PYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAW---NG 476

  Fly   271 RIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFPFT 332
            .:.:.::| .||.::............|.:|:.   |||   .||:....:|....:..|. |..
Mouse   477 MVGELVYG-RADVAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQKSKPGVFSFLD-PLA 536

  Fly   333 PLLWRAIGLVLILACLLLMLLVR-----WRHHHELPR----------NPY--YELLVLTMGGNLE 380
            ..:|..|....|...::|.|:.|     | |..|...          |.:  :..|..::|..::
Mouse   537 YEIWMCIVFAYIGVSVVLFLVSRFSPYEW-HSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ 600

  Fly   381 DRW--VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ----HFTIQ 439
            ...  .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::..::..|    :.|::
Mouse   601 QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLE 665

  Fly   440 LAEVNE--ARILASLPELRPEQLVYLEGSELQSFPALAQQ--------SGSSARVAILTPYEYFG 494
            .....|  .|...::.|   :...|::.:|...|....::        .|..|.:...|..||..
Mouse   666 AGSTKEFFRRSKIAVFE---KMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIE 727

  Fly   495 YFRKVHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEH-----WTRQYVS 554
            ..:....|.     |...:.::.......:.|.|.|.:|..:......|.|:.     |.
Mouse   728 QRKPCDTMK-----VGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWY----- 782

  Fly   555 AVDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLILWANLG- 618
               :|.|..::.:.:...|                        :.||:..:|.:|:::: ..||
Mouse   783 ---DKGECGSKDSGSKDKT------------------------SALSLSNVAGVFYILI-GGLGL 819

  Fly   619 AVVVFVLELLLPRIKLRKILRKMK 642
            |::|.::|..   .|.|...::||
Mouse   820 AMLVALIEFC---YKSRSESKRMK 840

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.