DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7b and Grik4

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	675	Identity:	123/675 - (18%)
Similarity:	243/675 - (36%)	Gaps:	161/675 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SEMGRFKTLYIYTHTNSQSTGGHLEELLDQVLMIVPNNL------------QARRLLLQQSMEYK 89
            :|:|.....|.|..||.:.:...::.|:|..:.|:..::            |:.....|::.::.
Mouse   232 AELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHV 296

  Fly    90 PYVHAVL--ALVDGLPSLSAIYARIRATQDLSHTLIYMSMPTDA-------YGEEMQATLRFLWR 145
            |:....|  ||:     ..|:||.:.|.|:|:.:......|...       :|..:...||.: .
Mouse   297 PFTGPALSSALL-----FDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMV-E 355

  Fly   146 LSVLNVGVVLRPPG---DHILMVSYFPFSALHGCQVISA-NVVNRYQVGTKRWASQDYFPSKLGN 206
            |..|...:.....|   ::.|.:..|   ..:|.|.|.. :|.....:.::.:||     :...:
Mouse   356 LEGLTGHIEFNSKGQRSNYALKILQF---TRNGFQQIGQWHVAEGLSMDSRLYAS-----NISDS 412

  Fly   207 FYGCLLTCATWEDMPYLVWR-----PDGSGSFVGIEGALLQFMAENLNFTV-------GLYWMNK 259
            .:...|...|..:.|||:.:     .:|:..:.|....:|:.:||.|.|..       |:|.:
Mouse   413 LFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGV-- 475

  Fly   260 EEVLATFDESGRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAY--- 321
            .|...|:  :|.: .|:....||.::.|..........|.:|:.   ||:  :.::.|...:
Mouse   476 PEANGTW--TGMV-GELIARKADLAVAGLTITAEREKVIDFSKP---FMT--LGISILYRVHMGR 532

  Fly   322 -SAYEKLSFPFTPLLWRAIGLVLILACLLLMLLVR-----WRHHHELPRNPYYELLV--LTMGGN 378
             ..|.....||:|.:|..:.|..:....:|.|:.|     |...|...:. ...|||  .::|.:
Mouse   533 RPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQG-RCNLLVNQYSLGNS 596

  Fly   379 LEDRW-------------VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISE 430
            |   |             .|:...:|.|...|...||::.|.|.:.:...|.......|.:::.:
Mouse   597 L---WFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDD 658

  Fly   431 VLAQHFTIQLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGY 495
             ||....|:...::..           ..:.:.:.|..|::..:               :.|. |
Mouse   659 -LADQTAIEYGTIHGG-----------SSMTFFQNSRYQTYQRM---------------WNYM-Y 695

  Fly   496 FRKVHPMSRRLHLVRERIYTQQLAF---------YVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQ 551
            .::.....:.......|:.....||         |.:|:.:|..:          .|.|:  |:.
Mouse   696 SKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQI----------GGLLD--TKG 748

  Fly   552 Y-----VSAV--DEKDESVARIASTSYSTL------DGIDGDPSLSESEEDQQVAPVRQNVLSMR 603
            |     |.:|  ||.|.::.::...:...:      :|     .....|||.     |...|.|.
Mouse   749 YGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEG-----GKCPKEEDH-----RAKGLGME 803

  Fly   604 ELAALFWLILWANLGAVVVFVLELL 628
            .:..:|.:::...:.|:.:.:||.|
Mouse   804 NIGGIFVVLICGLIVAIFMAMLEFL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	34/178 (19%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	75/423 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840