DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7b and grid2

DIOPT Version :9

Sequence 1:	NP_572410.2	Gene:	Ir7b / 31690	FlyBaseID:	FBgn0029965	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_031759030.1	Gene:	grid2 / 100487676	XenbaseID:	XB-GENE-955038	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	105/575 - (18%)
Similarity:	180/575 - (31%)	Gaps:	239/575 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LSAIYARIRATQDLSHTLIYMSMPTDAYGEEMQATLRFL--W-------------------RLSV 148
            :|.:...:..::|..:..||..:....||||:...:|.|  |                   |..|
Frog   378 VSGLTGALDFSEDGGNPNIYFEILGTNYGEELGRGIRKLGFWNPVTGLNGSLTDRKLENNMRGVV 442

  Fly   149 LNVGVVLRPPGDHILMVS---------YFPFSALHGCQVISANVVNRYQVGTKRWASQDYFPSKL 204
            |.|..||..|   .:|||         |..|| :.....:|:.:..:|::    :.:.|:   |.
Frog   443 LRVATVLEEP---FVMVSENVLGKPKKYQGFS-IDVLDALSSYLGFKYEI----YVASDH---KY 496

  Fly   205 GNFYGCLLTCATWEDMPYLVWRPDGSGSFVGIEGALLQFMAENLNFTVGLYWMNKEEVLATFDES 269
            |:                    |...||:.|:.|.||...|:          |....:..|.|..
Frog   497 GS--------------------PQADGSWNGLIGELLLKRAD----------MGISALTITPDRE 531

  Fly   270 GRIFDEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMSHIMLVTNLQSAYSAYEKLSFPFTPL 334
            ..:  :....:.|:|:|                         :|:...:.....:..|: ||...
Frog   532 NVV--DFTTRYMDYSVG-------------------------VLLRKAEKTVDMFACLA-PFDLS 568

  Fly   335 LWRAI-GLVLILACLLLMLLVRWRHHHELPRN-------------------------PYYELLVL 373
            ||..| |.||::.  ||:.|:.|.:...|...                         ||..|...
Frog   569 LWACIAGTVLLVG--LLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATR 631

  Fly   374 TMGGNLEDRWVPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFTI 438
            .|.|    .|             ||||.:|: |.|.:.:...|          |||.:
Frog   632 MMMG----AW-------------WLFALIVI-SSYTANLAAFL----------TISRI------- 661

  Fly   439 QLAEVNEARILASLPELRPEQLVYLEGSELQSFPALAQQSG------------SSARVAILTPYE 491
                                      .|.:||...|::|:.            ...||..:.|:|
Frog   662 --------------------------ESSIQSLQDLSRQTDIPYGTVFDSAVYEHVRVKGMNPFE 700

  Fly   492 YFGYFRKVHPMSRRLHLVRERIYTQQLAFYVRRH-------SHLVGVLNKQIQHAHTHGFLEHW- 548
                              |:.:|:|......|.:       ..|.|:  ::::|.: :.|:  |
Frog   701 ------------------RDSMYSQMWRMINRSNGSENNVQESLEGI--QKVKHGN-YAFV--WD 742

  Fly   549 --TRQYVSAVDEKDESVARIASTSYSTLDGI---DGDPSLSESEEDQQVAPVRQN 598
              ..:|: |::::|.|...:.:|......||   .|.|  ......|::..::||
Frog   743 AAVLEYI-AINDQDCSFYTVGNTIADRGYGIALQHGSP--YRDIFSQRILELQQN 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:415822	11/50 (22%)
grid2	XP_031759030.1	PBP2_iGluR_delta_2	440..806	CDD:270449	93/513 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910