Protein Alignment Ir7b and gria4

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 685
• Identity: 129/685 - (18%)
• Similarity: 244/685 - (35%)
• Gaps: 169/685 - (24%)

  Fly    39 MGRFKTLYIYTHTNSQSTGGHLEEL-LDQVLMIVPNNLQARRLLLQQSMEYKPYVHAVLALVDGL 102
            |.|:|||....:..|:|...:...| .|.||::.    :|.|:|.:|.::.....:|    .|.|
 Frog   276 MQRWKTLDQREYPGSESPPKYTSALTYDGVLVMA----EAFRILRRQKIDLSRRGNA----GDCL 332

  Fly   103 PSLSAIYARIRATQDLSHTL-------IYMSMPTDAYGEEMQATLRFLWRLSVLNVGVVLRPPG- 159
            .:.:|.:.:   ..|:..||       :..::..|.||..:..|:..   |.:.:.|  ||..|
 Frog   333 ANPAAPWGQ---GIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDV---LELKSNG--LRKIGY 389

  Fly   160 ----DHILMVSYFPFSALHGCQVISANVVNRYQVGTKRWASQDYFPSKLGNFYGCLLTCATWEDM 220
                |.::::.:.|     ..:..|:.:.||..:.|                        |..:.
 Frog   390 WNDMDKLVLLQHEP-----AFKNDSSGIENRTVIVT------------------------TILEA 425

  Fly   221 PYLVWRP-----DGSGSFVGIEGALLQFMAENLNFTV-------GLYWMNKEEVLATFDESGRIF 273
            ||::::.     :|:..|.|....|...:|:::....       |.|.....|   |...:|.:.
 Frog   426 PYVMYKKNHELLEGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSE---TKIWNGMVG 487

  Fly   274 DEIFGHHADFSLGGFHFKPSAGSEIPYSQSTYYFMS---HIMLVTNLQSAYSAYEKLSFPFTPLL 335
            :.::| .|:.::............|.:|:.   |||   .||:....:|....:..|. |....:
 Frog   488 ELVYG-KAEIAVAPLTITLVREEVIDFSKP---FMSLGISIMIKKPQKSKPGVFSFLD-PLAYEI 547

  Fly   336 WRAIGLVLILACLLLMLLVR---WRHHHELPR-----------NPY--YELLVLTMGGNLEDRW- 383
            |..|....|...::|.|:.|   :..|.|.|.           |.:  :..|..::|..::...
 Frog   548 WMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCD 612

  Fly   384 -VPQRFPSRLVLLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQ----HFTIQLAEV 443
             .|:....|:|...|.|.||::.|.|.:.:...|..:...:|.::..::..|    :.|:.....
 Frog   613 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGST 677

  Fly   444 NE--ARILASLPELRPEQLVYLEGSELQSF-----PALAQQSGSSARVAIL---TPYEYFGYFRK 498
            .|  .|...::.|   :...|::.:|...|     ..:|:...|..:.|.|   |..||....:.
 Frog   678 KEFFKRSKIAVYE---KMWTYMKSAEPSVFTKTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKP 739

  Fly   499 VHPMSRRLHLVRERIYTQQLAFYVRRHSHLVGVLNKQIQHAHTHGFLEHWTRQY--------VSA 555
            ...|.     |...:.::.......:||.|...:|..:...:..|.|:....::        ...
 Frog   740 CDTMK-----VGGNLDSKGYGVATPKHSQLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGG 799

  Fly   556 VDEKDESVARIASTSYSTLDGIDGDPSLSESEEDQQVAPVRQNVLSMRELAALFWLILWANLG-A 619
            .|.||::.|                                   ||:..:|.:|: ||...|| |
 Frog   800 GDSKDKTSA-----------------------------------LSLSNVAGVFY-ILVGGLGLA 828

  Fly   620 VVVFVLELLLPRIKLRKILRKMKSDIKKQISKLVR 654
            ::|.::|..   .|.|...::||....:.|....|
 Frog   829 MLVALIEFC---YKSRAEAKRMKLTFSEAIRNKAR 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	32/139 (23%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	74/420 (18%)