Protein Alignment Ir7b and grin2ca

DIOPT Version :10

• Sequence 1: NP_572410.2
• Gene: Ir7b / 31690
• FlyBaseID: FBgn0029965
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 812
• Identity: 148/812 - (18%)
• Similarity: 272/812 - (33%)
• Gaps: 316/812 - (38%)

  Fly    23 DWDLAEALAQVVANSEMGRFKTLYIYTHTNSQSTGGHLEELLDQVLMIVP----NNLQARRLLLQ 83
            :||     :.||..|....:.| |:....:...|...|.||.|.:...:.    |:|:|||||.|
Zfish   170 NWD-----SFVVVTSLYPGYDT-YVDYIRSFIDTSYFLWELQDTLTFDMSADGMNDLRARRLLQQ 228

  Fly    84 ------------QSMEY------------KPYVHAVLALVDGLPSLSAIYARIRATQDLSHTLIY 124
                        ...:|            ..|:..:.:|..|.|:::
Zfish   229 IDAQVLLVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSLAVGNPNIA------------------ 275

  Fly   125 MSMPTDAYGEEMQATLRFLWRLSVLN-----VGVV------------------------LRPPGD 160
               |.|::...:.:.:...|::|:.|     |.:|                        :||..:
Zfish   276 ---PPDSFPVGLISIITDRWKMSLRNRVRDGVAIVVKGVESFRKQRGFIPDGHMDCLSPIRPASN 337

  Fly   161 -----HILMVSY----FPFSALHGCQVISANVVNRYQVGTKRWASQDYFPSKLGNF--------- 207
                 |:|.||:    |.|:: .|..|..:.::.....| ::|       .|:||:
Zfish   338 GTLYRHMLNVSWENTDFSFNS-DGYLVNPSMIIITLDRG-RQW-------DKVGNYESGILQMRY 393

  Fly   208 -----YGCL---------LTCATWEDMPYLV-------------------WRPDGSGSFVG---- 235
                 ||..         ||.||.|:.|:::                   .:.:.:.:.||
Zfish   394 PVWPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEP 458

  Fly   236 -----IEG---ALLQFMAENLNFTVGLYWMNKEEVLATFDESGRI--------FDEIFGHHADFS 284
                 .:|   .:|:.::.|:.|:..||       |.|..:.|::        ..|:|...||.:
Zfish   459 YTKLCCKGFCIDILKKLSRNIKFSYDLY-------LVTNGKHGKLVRGIWNGMIGEVFYKRADMA 516

  Fly   285 LGGFHFKPSAGSEIPYSQSTYYFMSHIMLV-TNLQSAYSAYEKLSFPFTPLLWRAIGLVLILACL 348
            :|...........|.:|.........:|:. :|...:.||:.:   |::|.:|    :::.:.||
Zfish   517 IGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLE---PYSPAVW----VMMFVMCL 574

  Fly   349 LLMLLVRWRHHHELPRNPYYELLV---------LTMGGNLEDRW-------VPQRFP----SRLV 393
            .::.:..:...:..|.. |...||         .|:|.::...|       ||...|    |:::
Zfish   575 TVVAVTVFVFEYCSPVG-YNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIM 638

  Fly   394 LLTWLFATLVLRSGYQSGMYQLLRQDTQRNPPQTISEVLAQHFTIQLAEVNEARILASLPELRPE 458
            :|.|.|..::..:.|.:.:...:.|:...:   |:|.:..:.|.                  :|:
Zfish   639 VLVWAFFAVIFLASYTANLAAFMIQEQYID---TVSGLSDKKFQ------------------KPQ 682

  Fly   459 QLVYLEGSELQSFPALAQQSGSSARVAILTPYEYFGYFRKVHPMSRRLHLVRERIYTQQLAFYVR 523
                      ..:|                |:. ||    ..|.......:|..        |..
Zfish   683 ----------DQYP----------------PFR-FG----TVPNGSTERNIRSN--------YPE 708

  Fly   524 RHSHLVGVLNKQIQHAHTH---GFLEHWTRQYVSAV----DEKDESVARI--------ASTSYST 573
            .|||:|....|.::.|...   |.|:.:.  |.:||    ..|||....:        |:|.|
Zfish   709 MHSHMVKYNQKGVEDALNSLKTGKLDAFI--YDAAVLNYMAGKDEGCKLVTIGSGKVFATTGY-- 769

  Fly   574 LDGI---------------------DGD---------PSLSESEEDQQVAPVRQNVLSMRELAAL 608
              ||                     |||         ..:..:|:.:    |..:.|.:..:|.:
Zfish   770 --GIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLTGICRNEKKE----VMSSKLDIDNMAGV 828

  Fly   609 FWLILWANLGAVVVFVLELLLPRIKLRKILRK 640
            |:::|.|...:::||..|.|| ..|||..:||
Zfish   829 FYMLLVAMGLSLLVFAWEHLL-YWKLRHSVRK 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir7b	NP_572410.2	None
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..393	CDD:380601	47/258 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	82/481 (17%)
		NMDAR2_C	847..>938	CDD:463148	7/14 (50%)