DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7a and Ir7e

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001138176.1	Gene:	Ir7e / 7354417	FlyBaseID:	FBgn0259189	Length:	608	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	139/621 - (22%)
Similarity:	256/621 - (41%)	Gaps:	102/621 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VSPSQSTLAVMDLTQDAEHRDERQEQLMTIILRSVGSE-----MALRTFQKPPAEVPASFVVFLV 101
            |:||    .|:.|...:.|......::|:.:.|..|..     ..||.....|......|.|...
  Fly    40 VTPS----LVLTLCCRSNHTCNFYNKMMSTLFREWGLAPLQIVNVLRGVPWHPVPGRRHFNVIFT 100

  Fly   102 NSAQAFNTLGFHFTDIHSTREFN----FLILLTHRMSSRAERLQ-VLRDISRTCVRFHTSNVILL 161
            :|..||..:...:    .:||:|    :.|.|    .:|...|| .:|.|...|.|:...:..:.
  Fly   101 DSFAAFEEIRMEY----YSREYNYNEHYFIFL----QARDRLLQGEMRLIFDYCWRYRLIHCSIQ 157

  Fly   162 TEKRDGVVLVYAYRLLNMDCDLSVNLELIDIYKNGLFRHGHEARSFNRVL-SLSGCPLQVSWYPL 225
            .:|.:|.:|.|:|..........:..:||:.|...:.   .|...|.|.| :..||||:.:.:.:
  Fly   158 VQKSNGDILFYSYYPFGEHGCSDMEPQLINRYNGSML---VEPDLFPRKLRNFFGCPLRCALWDV 219

  Fly   226 PPFVSFIGNSSDPEERAQIWRLT-GIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSGCF- 288
            |||::.      .|::.::.|:. |.:|.|:..||...:|.|.:.:     :..:::|:.....
  Fly   220 PPFLTL------DEDQEEVLRVNGGYEGRLLLALAEKMNFTIAVRK-----VHVNMRDEALEMLR 273

  Fly   289 -DQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVF-IMHMSSQFGAVAQLAVPFTVIVWLA 351
             |:|.::...|......|.....||     :|||:..|| ::..|.:..:...|..|:.:.:|:.
  Fly   274 RDEVDLTLGGIRQTVARGMVATSSH-----NYHQTREVFGVLASSYELSSFDILFYPYRLQIWMG 333

  Fly   352 LV----VSSLLLVLV-----------LWMRNRLVCGRSDLASHALQVLTTLMGNPLEARSLPRSS 401
            ::    :|:|:.::|           .|:...||                .:|.||  ...|||.
  Fly   334 ILGVVALSALIQLIVGRMLRERMGSRFWLNLELV----------------FVGMPL--LECPRSH 380

  Fly   402 RLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHKPLPTEISELIRSNYTL----INQEYLDYYP- 461
            ..|:.....::..|::|.:|||.|:...|.......|..|..|::.|:|:    |.||.||..|
  Fly   381 TARLYCVMLMMYTLIIRTIYQGLLYHLIRTHQLNRWPQTIESLVQKNFTVVLTPIVQEVLDEIPS 445

  Fly   462 ---RELTVLTRNGSKDRFDYIQGLGKEGKFTTTSLIATMEYYNMM----------HWSTSRLTHI 513
               ....:|..|...|...:::...:..:..|.|.:....::|.:          ..|.:....:
  Fly   446 VQHMRFRLLEANSELDPLYFLEANHQLRQHVTASALDIFIHFNRLSADKVHQRGEQGSGAHFEIV 510

  Fly   514 KEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGIIGYFVR-EFDACQYRKPFEEDYEVTPIPLD 577
            .|.|...|:.:||.:||.|....:.:|..:.|.|::..:.| |......|.  |:.::|  :...
  Fly   511 PEDIISMQLTMYLAKHSFLIDQLNEEIMWMRSVGLLSVWSRWELSESYLRN--EQSFQV--LGTM 571

  Fly   578 SFCGLYYISLIWLSAAVVAFILELLSQRIVWLRRIF 613
            ....::.:.|:.|...::.|||||:|.|.::||::|
  Fly   572 ELYAIFLMVLVGLIVGLLVFILELVSMRSIYLRKLF 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Ir7e	NP_001138176.1	PBPb	218..>313	CDD:214497	24/110 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25775
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007621
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920