DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and grid2

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_001004123.1	Gene:	grid2 / 448841	ZFINID:	ZDB-GENE-040913-1	Length:	1009	Species:	Danio rerio

Alignment Length:	657	Identity:	119/657 - (18%)
Similarity:	248/657 - (37%)	Gaps:	104/657 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MTPLVAAALEILAEQVSPSQSTLAVMDLTQDAEHRDERQEQLMTIILRSVGSEMALR-TFQKPPA 90
            |:|..|.|  .:.|.|   ::.|...|......:.:.....:..::::|:|....:| ||
Zfish   234 MSPATAKA--FITEVV---ETNLVAFDCQWIIINEEISDMDVQELVMKSIGRLTLVRQTF----- 288

  Fly    91 EVPASFVVFLVNSAQAFNTL-------GFHFTDIHSTREFNFLILLTHRMSSRAERLQVLRDISR 148
            .:|.:.....|.:....||.       .....:|.:...::.::||.:....:.|..:.....|.
Zfish   289 PLPQNTSQRCVRNNHRINTSLCDPKDPKAQMLEITNRYIYDTVLLLANTFHRKLEDRKWHSMASL 353

  Fly   149 TCVR-----FHTSNVILLTEKRDGVV-LVYAYRLLNMDCDLSVNLELI-----DIYKNGLFR--- 199
            :|:|     :.....:|.|.|:.||. |.......:...:.:::.|::     :....|:.|
Zfish   354 SCIRKGSKPWQGGKSMLETVKKGGVSGLTSLLEFNDNGSNPNIHFEILGTNYGEDRGRGVSRLAT 418

  Fly   200 ----HGHEARSFNRVL--SLSGCPLQVSWYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLL 258
                ||......:|.|  ::.|..|:|......|||....|.....::.|     |...:::..|
Zfish   419 WDPIHGLNGTLTDRKLENNMRGVVLRVVTVLEEPFVMVSENVLGKPKKYQ-----GFSIDVLDAL 478

  Fly   259 ASIFDFRI-LLEEPCNKCLSPDIKDDCSGCFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQS 322
            |:...|:. :...|.:|..|.......:|...:::...:.:.:.|::.:.:..|...||:.|...
Zfish   479 ANYLGFKYEIYVAPDHKYGSQQADGTWNGLIGELVFKRADVGLSALTITPERESVVDFTTRYMDY 543

  Fly   323 SLVFIMHMSSQFGAVAQLAVPFTVIVWLALVVSSLLLVLVLWMRNRLVCGRSDLASHALQVLTTL 387
            |:..::..:.:...:.....||.:.:|..:..:.||:..::::.|.|...|..:.|    |.:|.
Zfish   544 SVGVLLRKAERTVDMFACLAPFDLSLWACIAGTVLLVGTLVYLLNWLNPPRLPMGS----VSSTT 604

  Fly   388 MGNPL---------EARSLPRSS-RLRILYAGWLLLVLVLRVVYQGKL------------FDSFR 430
            :.|.:         :...:|.:: ..|::...|.|..|::...|...|            ..|.:
Zfish   605 LYNSMWFVYGSFVQQGGEVPYTTLATRMMMGVWWLFALIVISSYTANLAAFLTISRIENSIQSLQ 669

  Fly   431 -------LPYHKPLPTEISELIRSNYTLINQEYLD-YYPRELTVLTRNG--------SKDRFDYI 479
                   |||...|.:.:.:.:||..  :|....| .|.:...::.|.|        ||:....:
Zfish   670 DLAKQTDLPYGTVLDSAVYDQVRSKG--MNPFERDPMYSQMWRMINRTGGAENNVEESKEGIRKV 732

  Fly   480 QGLGKEGKFTTTSLIATMEYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLL 544
                |.|:|......|.:||..:.....|..| :..::......:.::..|..:..|.::|.:|.
Zfish   733 ----KYGRFAFVWDAAVLEYVAINDEDCSLYT-VSNNVADRGYGMAMQHGSPYRDIFSQRILELQ 792

  Fly   545 SAG-----IIGYFVREFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLIWLSAAVVAFILELLSQ 604
            ..|     .:.::.|: ..|....|.......:.:.:.||.|::::    |:|.||...| :.:.
Zfish   793 QNGDMDILKLKWWPRD-SPCDLYSPVGTRKSGSALDIHSFAGVFFV----LAAGVVLSCL-IATV 851

  Fly   605 RIVWLRR 611
            ...|.||
Zfish   852 ETWWTRR 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
grid2	NP_001004123.1	PBP1_iGluR_delta_2	28..427	CDD:107386	35/202 (17%)
		ANF_receptor	42..404	CDD:279440	31/179 (17%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	68/381 (18%)
		Lig_chan	568..841	CDD:278489	51/288 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	989..1009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810