DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir7a and gria1b

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_991293.1	Gene:	gria1b / 403044	ZFINID:	ZDB-GENE-020125-2	Length:	917	Species:	Danio rerio

Alignment Length:	197	Identity:	39/197 - (19%)
Similarity:	75/197 - (38%)	Gaps:	33/197 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 VLRVVYQGKLFDSFRLPYHKPLPTEISE----LIRSNY-TLINQEYLDYYPRELT--VLTRNGSK 473
            |....|...|.::|.|.....:.|.|.|    :::.|: .|:..:..:.|..||.  :....|..
Zfish   387 VSTATYSNMLNETFGLQNRTYVVTTILEAPYVMLKKNHEQLVGNDKYEGYCVELAAEIAKHVGYS 451

  Fly   474 DRFDYIQGLGKEGKFTTTSLIATMEYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDR 538
            .|.:.: |.||.|.....::        |.:.....|.:.|..:.:..:.|.|.|..::.|:
Zfish   452 YRLELV-GDGKYGARDAETM--------MWNGMVGELVYGKADVAVAPLTITLVREEVIDFS--- 504

  Fly   539 KIKQLLSAGIIGYFVREFDACQYRKPFEEDYEVTPIPLDSFCGLYYISLI--WLSAAVVAFILEL 601
              |..:|.||         :...:||.:....|... ||......::.::  ::..:||.|::..
Zfish   505 --KPFMSLGI---------SIMIKKPTKSKPGVFSF-LDPLAYEIWMCIVFAYIGVSVVLFLVSR 557

  Fly   602 LS 603
            .|
Zfish   558 FS 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..387	CDD:107385	39/197 (20%)
		ANF_receptor	41..368	CDD:279440
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	34/180 (19%)
		Lig_chan	536..842	CDD:278489	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900