DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir7a and Ir40a

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_610140.4	Gene:	Ir40a / 35449	FlyBaseID:	FBgn0259683	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	148/760 - (19%)
Similarity:	265/760 - (34%)	Gaps:	187/760 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLWLLMGLRSLAMGALHPPQ------PEAMTPLVAAALEILAEQVSPSQSTLAVMDL----TQDA 58
            |.:|.:||....:|.|:..:      .|:.|   |.||..:...:  .||:||::.|    ..|.
  Fly     2 HKFLALGLLPYLLGLLNSTRLTFIGNDESDT---AIALTQIVRGL--QQSSLAILALPSLALSDG 61

  Fly    59 EHRDERQEQLMTIILR-------SV---GSEMALRTFQKPPAEVPASFVVFLVNSAQAFNTLGFH 113
            ..:.||...|...:.|       ||   .:|:..:..::..........:.|....|..|:|  |
  Fly    62 VCQKERNVYLDDFLQRLHRSNYKSVVFSQTELFFQHIEENLQGANECISLILDEPNQLLNSL--H 124

  Fly   114 FTDIHSTREFNFLILLTHRMSSRAERLQVLRDISRTCVRFHTS-NVILLTEKRDGVVLVYAYRLL 177
              |.|          |.||:|............|...:||... .|:::|..|.....:|..:.
  Fly   125 --DRH----------LGHRLSLFIFYWGARWPPSSRVIRFREPLRVVVVTRPRKKAFRIYYNQA- 176

  Fly   178 NMDCDLSVNLELIDIYKN---GLFRHGHEARSFNRVLSLSGCPLQVSWYPLPP--FVSFIGNSSD 237
             ..|..| .|:|::.|..   ||.|......:.:...:..|...:|..:..||  :|::..||.:
  Fly   177 -RPCSDS-QLQLVNWYDGDNLGLQRIPLLPTALSVYANFKGRTFRVPVFHSPPWFWVTYCNNSFE 239

  Fly   238 PE---------ERAQIWRLTGIDGELIKLLASIFDFRI-LLEEPCNKCLS------PDIKDDCSG 286
            .:         |:.::....|.|..|:.||:...:||. .:|.|.....|      .|..|..:|
  Fly   240 EDEEFNSLDSIEKRKVRVTGGRDHRLLMLLSKHMNFRFKYIEAPGRTQGSMRSEDGKDSNDSFTG 304

  Fly   287 CFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFGAVAQLAVPFTVIVWLA 351
            ....:....:...:|.:..|.:.|....|:......|..|..|...:......:..||...:|..
  Fly   305 GIGLLQSGQADFFLGDVGLSWERRKAIEFSFFTLADSGAFATHAPRRLNEALAIMRPFKQDIWPH 369

  Fly   352 LVVS---------SLLLVLVLWMR---NRLVCGRSDLASHA--LQVLT--TLMGNP---LEARSL 397
            |:::         .::.:..:|.|   |..|....:|..|.  |:.:|  .|...|   |.|..:
  Fly   370 LILTIIFSGPIFYGIIALPYIWRRRWANSDVEHLGELYIHMTYLKEITPRLLKLKPRTVLSAHQM 434

  Fly   398 P---------------------------RSSRLRILYAGWLLLVLVLRVVYQGKLFDSFRLPYHK 435
            |                           |:..|.|:|  |:....||..||..:|...|..|..:
  Fly   435 PHQLFQKCIWFTLRLFLKQSCNELHNGYRAKFLTIVY--WIAATYVLADVYSAQLTSQFARPARE 497

  Fly   436 PLPTEISELIRSNYTLINQEYLDYYPRELTVL--TRNGSKDRFDYIQGLGK-------EGKFTTT 491
            |   .|:.|.|....:|:..|..|..:|.:.|  ..||: :.|..:..|.:       :|.|..:
  Fly   498 P---PINTLQRLQAAMIHDGYRLYVEKESSSLEMLENGT-ELFRQLYALMRQQVINDPQGFFIDS 558

  Fly   492 -----SLIA-------------TMEYYNMMHWSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDR 538
                 .|||             |: ::|:..:.::.. .:.:.::.....:.::.......:.:.
  Fly   559 VEAGIKLIAEGGEDKAVLGGRETL-FFNVQQYGSNNF-QLSQKLYTRYSAVAVQIGCPFLGSLNN 621

  Fly   539 KIKQLLSAGIIGYFVREFDACQYRKPFE-----------------------EDYE---VTPIPLD 577
            .:.||..:||:.    :..|.:|.|.::                       |.|:   ::|:.|.
  Fly   622 VLMQLFESGILD----KMTAAEYAKQYQEVEATRIYKGSVQAKNSEAYSRTESYDSTVISPLNLR 682

  Fly   578 SFCGLYYISLIWLSAAVVAFILE------------LLSQRIVWLR 610
            ...|.:....:...||.|..:||            :|..|:.|:|
  Fly   683 MLQGAFIALGVGSLAAGVILLLEIVFIKLDQARLWMLCSRLQWIR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir7a	NP_572406.1	None
Ir40a	NP_610140.4	PBP2_LTTR_substrate	216..338	CDD:330233	24/121 (20%)
		Periplasmic_Binding_Protein_Type_2	297..>391	CDD:328725	14/93 (15%)
		Periplasmic_Binding_Protein_Type_2	<496..637	CDD:328725	24/150 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42643
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100