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Protein Alignment Ir7a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_572406.1	Gene:	Ir7a / 31686	FlyBaseID:	FBgn0029961	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	714	Identity:	139/714 - (19%)
Similarity:	241/714 - (33%)	Gaps:	215/714 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HLWLLMGLRSLAMGAL----HPPQPEAMTPLVAAALEI--------LAEQVSPSQSTLA------ 50
            ::|.::|.:....|..    .||......||.|....:        ||.:|:...:.:|
Human   270 YVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQAL 334

  Fly    51 ------VMDLTQD--AEHRDERQEQLMTIILRSVGSEMALRTFQKPPAEVPASFVVFLVNSAQAF 107
                  :.:|..|  |::|..|.|.|....:.                       :...|...:|
Human   335 LRDYGFLPELGHDCRAQNRTHRGESLHRYFMN-----------------------ITWDNRDYSF 376

  Fly   108 NTLGF----HFTDIHSTREFNFLIL---------LTHRMSSRAER-LQVLRDISRTCVRFHTSNV 158
            |..||    ....|..||:..:.::         |.:.:.||..| ||.:.|         |.::
Human   377 NEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDD---------TQHL 432

  Fly   159 ILLT-EKRDGVVLVYAYRLLNMDCDLSVNLELIDIYKNGLFRHGHEARS-FNRVLSLSGCPLQVS 221
            .:.| |:|..|:                 :|..|.......|.....|| .||..|
Human   433 TVATLEERPFVI-----------------VEPADPISGTCIRDSVPCRSQLNRTHS--------- 471

  Fly   222 WYPLPPFVSFIGNSSDPEERAQIWRLTGIDGELIKLLASIFDFRILLEEPCNKCLSPDIKDDCSG 286
                ||     .::..||:|.    ..|...:::|.||....|...|....|......|....:|
Human   472 ----PP-----PDAPRPEKRC----CKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNG 523

  Fly   287 CFDQVIISNSSILIGAMSGSHQHRSHFSFTSSYHQSSLVFIMHMSSQFGAVAQLAV--PFTVIVW 349
            ...:|....:.:.||:::.:.:......|:..:.::.:..::..|:  |.|:..|.  |::..||
Human   524 MIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN--GTVSPSAFLEPYSPAVW 586

  Fly   350 LALVVSSLLLVLV----------LWMRNRLVCGRSDLAS-----HALQVLTTLMGN---PLEARS 396
            :.:.|..|.:|.|          :.....|..|:....|     .::.:|..|:.|   |:|.
Human   587 VMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVEN-- 649

  Fly   397 LPRSSRLRILYAGWLLLVLVLRVVY---------QGKLFDS--------FRLPYHKPLPTEISEL 444
             ||.:..:|:...|....::....|         |.:..|:        |:.|..:..|.:...:
Human   650 -PRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTV 713

  Fly   445 --------IRSNYTLINQEYLDY-YPRELTVLT--RNGSKDRFDY------IQGLGKEG-KFTTT 491
                    |||||..::...:.| .||....||  :.|..|.|.|      ......|| |..|.
Human   714 PNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTI 778

  Fly   492 ---SLIATMEYYNMMH----WSTSRLTHIKEHIFLYQMVIYLRRHSLLKFAFDRKIKQLLSAGII 549
               .:.||..|...:|    |        |..|.|          :||:|..|.:|:.|....:.
Human   779 GSGKVFATTGYGIALHKGSRW--------KRPIDL----------ALLQFLGDDEIEMLERLWLS 825

  Fly   550 GYFVREFDACQYRKPFEEDYEV--TPIPLDSFCGLYYISLIWLSAAVVAFILELLSQRIVWLRR 611
            |       .|.     .:..||  :.:.:|:..|::|:.|:.:..:::.|..|.|   :.|..|
Human   826 G-------ICH-----NDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL---VYWRLR 874

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.